Primary graft failure after myeloablative allogeneic hematopoietic cell transplantation for hematologic malignancies

Leukemia
R OlssonK R Cooke

Abstract

Clinical outcomes after primary graft failure (PGF) remain poor. Here we present a large retrospective analysis (n=23,272) which investigates means to prevent PGF and early detection of patients at high risk. In patients with hematologic malignancies, who underwent their first myeloablative allogeneic hematopoietic cell transplantation, PGF was reported in 1278 (5.5%), and there was a marked difference in PGFs using peripheral blood stem cell compared with bone marrow grafts (2.5 vs 7.3%; P<0.001). A fourfold increase of PGF was observed in myeloproliferative disorders compared with acute leukemia (P<0.001). Other risk factors for PGF included recipient age <30, HLA mismatch, male recipients of female donor grafts, ABO incompatibility, busulfan/cyclophosphamide conditioning and cryopreservation. In bone marrow transplants, total nucleated cell doses ⩽2.4 × 10(8) per kg were associated with PGF (odds ratio 1.39; P<0.001). The use of tacrolimus-based immunosuppression and granulocyte colony-stimulating factor were associated with decreased PGF risk. These data, allow clinicians to do more informed choices with respect to graft source, donor selection, conditioning and immunosuppressive regimens to reduce the risk of PGF. Moreover...Continue Reading

References

Jun 1, 1976·Archives of Disease in Childhood·F L JohnsonR Storb
Nov 1, 1985·Transfusion·J G Kelton, G Bebenek
Jul 1, 1971·The Journal of Experimental Medicine·G Cudkowicz, M Bennett
Dec 18, 1982·Lancet·E D Thomas, R Storb
Mar 4, 1983·JAMA : the Journal of the American Medical Association·M M BortinA A Rimm
Dec 26, 2001·The New England Journal of Medicine·E W PetersdorfC Anasetti
Jul 22, 2006·Transplantation·Martin SternUNKNOWN Aplastic Anemia Working Party of the European Group for Blood and Marrow Transplantation
Dec 2, 2006·Blood·Rima M SalibaDaniel R Couriel
May 29, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mats RembergerAgneta Wikman
Jan 1, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jonas MattssonRainer Storb
Mar 18, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ryotaro NakamuraStephen J Forman
Jun 11, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Daniel WeisdorfJohn Klein
Nov 10, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Andrea BacigalupoMary Horowitz
Feb 23, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jeffrey SchriberMarcelo C Pasquini
Aug 6, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Hyoung Jin KangUNKNOWN Korean Society of Pediatric Hematology-Oncology
Oct 16, 2010·Clinical Transplantation·Mats RembergerOlle Ringdén
Mar 9, 2011·Transfusion·Jennifer Daniel-Johnson, Joseph Schwartz
May 10, 2011·Bone Marrow Transplantation·J AbelssonUNKNOWN Nordic MPD Study Group
Mar 28, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Karen K BallenWael Saber
Jun 5, 2012·Bone Marrow Transplantation·L J FernyhoughB D Hock
Dec 12, 2012·Bone Marrow Transplantation·G AkpekV T Ho
Dec 12, 2012·Bone Marrow Transplantation·R OlssonO Ringden

❮ Previous
Next ❯

Citations

Feb 24, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jane ApperleyYoshihisa Kodera
Jan 24, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sandra LangeChristian Junghanss
Nov 3, 2015·Bone Marrow Transplantation·R P Gale
Nov 10, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jane ApperleyYoshihisa Kodera
Feb 28, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Fleur M AungUday Popat
May 2, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Yu-Tong WangXiao-Jun Huang
Oct 4, 2016·Frontiers in Immunology·Stavroula Masouridi-LevratYves Chalandon
Apr 15, 2020·Leukemia·Juan Carlos Hernández-BoludaIbrahim Yakoub-Agha
Jul 1, 2020·American Journal of Hematology·Piyanuch KongtimStefan O Ciurea
Jan 24, 2019·Bone Marrow Transplantation·Shin-Ichiro FujiwaraUNKNOWN HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation
Feb 14, 2020·Bone Marrow Transplantation·Kaito HaradaUNKNOWN transplant complications working group of the Japan Society for Hematopoietic Cell Transplantation
Oct 28, 2020·American Journal of Hematology·Jean-Baptiste BossardUNKNOWN Société Francophone de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC), the France-Intergroupe des Syndromes Myéloproli
May 24, 2020·Cancer Immunology Research·Melody CheongGeoffrey R Hill
Jan 24, 2021·Pediatric Blood & Cancer·Pietro MerliFranco Locatelli
Dec 18, 2020·Bone Marrow Transplantation·Sabrina GiammarcoEmanuele Angelucci
Mar 21, 2021·Pediatric Transplantation·M Luz Uria-OficialdeguiCristina Diaz-de-Heredia
Jun 23, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Yang SongYuan Kong
May 8, 2019·Bulletin du cancer·Vincent AlcazerHélène Labussière-Wallet
May 13, 2021·Health Science Reports·Mohammad RafieeMohammad Hossein Mohammadi
May 22, 2021·Frontiers in Immunology·Andrea BacigalupoValerio De Stefano

❮ Previous
Next ❯

Methods Mentioned

BETA
MDS
biopsy

Software Mentioned

SAS

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood Group Incompatibility

Blood group incompatibility between donor and recipient has been associated with poor transplant outcomes. Discover the latest research on blood group icompatibility here.