PMID: 16529329Mar 15, 2006Paper

Primary grafting research of tissue engineered oral mucosa lamina propria on skin full thickness wounds

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Zhi-Qiang WuTao Jiang

Abstract

To study the allograft effect of two kinds of tissue engineered oral mucosa lamina propria on skin full-thickness wounds. The cultured Wistar rat oral mucosa fibroblasts (OMF) were incorporated into collagen or chitosan-collagen to construct the tissue engineered oral mucosa lamina propria, and then the OMFs were labeled with BrdU. The full-thickness round skin defects were made with a round knife (diameter, 0.8 cm) on the backs of 36 Wistar rats (21-25 weeks old), which were divided into 2 experimental groups: the fibroblast-populated collagen lattices (FPCL) group (grafted by FPCLs) and the fibroblast-populated chitosan collagen lattices (FPCCL) group (grafted by FPCCLs), and the control group (only covered with gauges). All the wounds were observed by the naked eyes or the light microscope, and were measured 4, 7, 14, and 21 days postoperatively. There were no infection during the wound healing period. At 7 days after the grafting, the wounds in the 3 groups were covered by scab and/or gauze; at 14 days, the gauze and scab on the wounds in the three groups were all replaced by the new epidermis naturally except one scab each in the FPCCL group and the control groups, which was replaced at 17 days. All the centers of the new ...Continue Reading

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