Primary hepatic Epstein-Barr virus-associated CD30-positive peripheral T-cell lymphoma of cytotoxic phenotype

Experimental and Molecular Pathology
Yue PengXin Qing

Abstract

Primary hepatic peripheral T-cell lymphoma (PTCL) is exceedingly rare. We encountered such a case in a 58-year-old Hispanic female with a history of chronic sinusitis and hypothyroidism who presented with 4weeks of fever and weight loss. Laboratory studies showed altered liver function and mild pancytopenia. Hepatitis and HIV infection were excluded by negative serological tests. A computed tomography (CT) scan showed innumerable small low-density lesions throughout the liver without splenomegaly or lymphadenopathy. CT-guided liver core biopsy showed scattered small lymphoid aggregates located mainly in the portal tracts and periportal regions. Within the lymphoid aggregates, scattered large pleomorphic lymphoma cells were seen, admixed with smaller lymphoid cells and histiocytes. By immunohistochemistry, the lymphoma cells expressed CD2, CD3, CD8, CD30, CD43, CD45, granzyme B, TIA-1, and negative for CD4, CD5, CD7, CD56, βF1, ALK-1, and B-cell markers. In situ hybridization for Epstein-Barr virus-encoded RNA (EBER) was positive in some lymphoma cells. To our knowledge, this is the first reported case of primary hepatic Epstein-Barr virus-associated PTCL with CD30 expression.

References

Dec 1, 1990·Journal of Clinical Pathology·P P AnthonyT Clarke
Mar 1, 1973·Archives of Internal Medicine·D J FergusonJ E Ultmann
Jan 1, 1972·Cancer·C FreemanS J Cutler
Apr 10, 2002·American Journal of Clinical Pathology·Thomas A HemburyEric D Hsi
Apr 26, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philip WentStefano A Pileri
Mar 23, 2011·Internal Medicine·Kazuho MiyashitaYoshiaki Ishigatsubo
Apr 24, 2013·BMJ Case Reports·S MishraA Kumar
Jun 25, 2014·Oncology Letters·Hui-Juan HuYan-Juan Qu

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Citations

Feb 10, 2016·Experimental and Molecular Pathology·Yue PengXin Qing
Aug 2, 2018·Journal of Cellular Physiology·Saeed Mohammadian HaftcheshmehAmirhossein Sahebkar
Mar 13, 2018·World Journal of Hepatology·Daryl RamaiMadhavi Reddy

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