Primary hepatic gastrinoma being diagnosed preoperatively: a case report and literature review

Surgical Case Reports
Shunya HanzawaNorihisa Takakura

Abstract

A majority of gastrinomas causing Zollinger-Ellison syndrome are located in the duodenum or pancreas. Primary hepatic gastrinomas are rare and difficult to diagnose. We report a rare case of primary hepatic gastrinoma, which could be diagnosed preoperatively. A 29-year-old man with a 55-mm tumor in segments 5 and 6 (S 5/6) of the liver was admitted to our hospital. After thorough investigations, he was treated for a suspected inflammatory pseudotumor and advised to undergo routine follow-up. Two years later, he revisited our hospital with a complaint of abdominal pain, vomiting, and diarrhea. Upper gastrointestinal endoscopy revealed multiple duodenal ulcers. His serum gastrin level was 2350 pg/mL (normal: 37-172 pg/mL), suggesting Zollinger-Ellison syndrome. Abdominal computed tomography showed a 78-mm hypervascular tumor with cystic degeneration in the S 5/6 region of the liver, with a potential to increase over time. The tumor showed hypointensity on T2-weighted and hyperintensity on diffusion-weighted abdominal contrast-enhanced magnetic resonance imaging. Somatostatin receptor scintigraphy (SRS) only detected a hepatic tumor. No tumors in the gastrinoma triangle were detected by endoscopic ultrasonography. Hence, selective...Continue Reading

References

Nov 1, 1992·Ultrastructural Pathology·J Larriva-SahdM Campuzano Fernández
Mar 1, 1989·The British Journal of Surgery·J C ArnoldR Williams
Jun 24, 1982·The New England Journal of Medicine·M M WolfeJ E McGuigan
Nov 1, 1984·Journal of Pediatric Gastroenterology and Nutrition·A L Smith, A W Auldist
May 1, 1983·Annals of Surgery·J C ThompsonC M Townsend
Sep 1, 1993·Cancer·S MoriuraS Gotou
Apr 1, 1997·Journal of Clinical Gastroenterology·E TiomnyT Gilat
Jun 12, 1999·The British Journal of Radiology·D KehagiasL Vlahos
Aug 26, 1999·The New England Journal of Medicine·J A NortonR T Jensen
Nov 24, 1999·The American Journal of Gastroenterology·V SmyrniotisA Paphitis
Apr 3, 2001·Digestive Diseases and Sciences·R N ChienY F Liaw
Aug 20, 2003·Digestive Diseases and Sciences·Roberto DíazVeronica Calderero
Nov 18, 2004·American Journal of Obstetrics and Gynecology·Jorge DelgadoAlex Fich
Mar 24, 2005·Abdominal Imaging·S UlusanS Yildirim
Jul 26, 2006·Digestive Diseases and Sciences·Chikashi ShibataIwao Sasaki
Oct 17, 2007·The British Journal of Surgery·V FendrichM Rothmund
May 25, 2011·World Journal of Gastrointestinal Pathophysiology·Konstantinos TsalisGeorgios Kartalis
Dec 29, 2012·Case Reports in Gastroenterology·Hideaki NaoeYutaka Sasaki
Aug 26, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Satoshi OgawaYukihiro Imai
Nov 29, 2017·Surgical Case Reports·Takaomi HagiMasayuki Imamura
Aug 7, 2018·World Journal of Hepatology·Leonardo Zumerkorn PipekWellington Andraus

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Satoshi OgawaYukihiro Imai
The American Journal of Gastroenterology
V SmyrniotisA Paphitis
Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Eric H TwerdahlRichard A Hodin
Digestive Diseases and Sciences
Roberto DíazVeronica Calderero
© 2021 Meta ULC. All rights reserved