Primary hepatic lymphoma presenting as fulminant hepatic failure with hyperferritinemia: a case report.

Journal of Medical Case Reports
Fyeza S HaiderSharif Khan

Abstract

Primary hepatic lymphoma is an unusual form of non-Hodgkin's lymphoma that usually presents with constitutional symptoms, hepatomegaly and signs of cholestatic jaundice. Diffuse hepatic infiltration is uncommon and presentation with acute hepatic failure even more rare. The presence of markedly elevated ferritin levels can complicate the evaluation process and suggest alternative diagnoses.We present the case of a middle-aged woman exhibiting pancytopenia, hyperferritinemia and rapidly deteriorating to develop acute hepatic failure. Her initial clinical picture led to a working diagnosis of adult onset Still's disease with probable hemophagocytic syndrome before her worsening liver function necessitated a percutaneous liver biopsy and establishment of the final diagnosis of primary hepatic lymphoma. Primary hepatic lymphoma is an uncommon malignancy and its manifestation as progressive hepatitis or acute fulminant hepatic failure can be difficult to diagnose. The presence of constitutional symptoms, pancytopenia and high ferritin levels can complicate the evaluation process. A liver biopsy early in the course of liver dysfunction may establish the diagnosis without a higher risk of bleeding complications seen once liver failure...Continue Reading

References

Jan 15, 1989·Annals of Internal Medicine·L D KaplanJ Cello
Feb 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C HanauR Rubin
Jul 23, 2003·The American Journal of Gastroenterology·Christopher J Lettieri, Benjamin W Berg
Sep 24, 2004·Age and Ageing·Nancy Agmon-LevinZev M Sthoeger
Mar 2, 2006·Clinical Lymphoma & Myeloma·J Stuart SalmonJohn P Greer

❮ Previous
Next ❯

Citations

Aug 13, 2009·Current Oncology·A MasoodN C Gupta
Jun 21, 2014·Case Reports in Oncological Medicine·D MyoteriA Zizi-Sermpetzoglou
Jan 16, 2014·The Indian Journal of Surgery·Young-Dong YuSung-Ock Suh
Jun 26, 2014·Journal of Gastrointestinal Cancer·Meryem AitelhajHassan Errihani
Nov 22, 2014·Clinical Rheumatology·Rema BisharaAlexandra Balbir-Gurman
Feb 1, 2012·Clinical Journal of Gastroenterology·Naoki KonnoHiromasa Ohira
May 1, 2013·Gastroenterología y hepatología·Octavio MuñozGonzalo Correa
Feb 24, 2016·Journal of Clinical and Experimental Hepatology·Aabha NagralAnita Borges
Nov 30, 2010·Clinics in Liver Disease·Marvin M Singh, Paul J Pockros
Nov 20, 2015·Seminars in Arthritis and Rheumatism·Katharina HofheinzBernhard Manger
Dec 30, 2014·Clinics and Research in Hepatology and Gastroenterology·Hiroyuki AbeYutaka Aoyagi
Apr 23, 2013·International Journal of Hepatology·Jun Murakami, Yukihiro Shimizu
Jun 10, 2015·Journal of the American Academy of Dermatology·Natalie Z SunKanade Shinkai
Mar 15, 2015·Current Problems in Diagnostic Radiology·Ekta DhamijaArun K Gupta
Dec 2, 2014·Oncology Letters·Guo-Bin WuLE-Qun Li
Jul 1, 2012·Archives of Trauma Research·Rouhullah DehghaniMohammd Sabahi Bidgoli
Jun 25, 2014·Oncology Letters·Hui-Juan HuYan-Juan Qu
Feb 20, 2016·Experimental and Therapeutic Medicine·Hui-Juan HuZai-Peng Zhang
Jan 11, 2020·Clinical Journal of Gastroenterology·Kimitoshi KuboMototsugu Kato
Jun 2, 2020·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Fabio MarazziVincenzo Valentini
Sep 27, 2020·Journal of Medical Case Reports·Eduardo DantasAna Paula Oliveira

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
glycosylation

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Adult-Onset Still's Disease

Adult-onset Still's disease (AOSD) is a form of Still's disease, a rare systemic autoinflammatory disease characterized by the classic triad of persistent high spiking fevers, joint pain, and a distinctive salmon-colored bumpy rash. Discover the latest research on AOSD here.