PMID: 9554532Apr 29, 1998Paper

Primary heterologous carcinosarcoma (metaplastic carcinoma) of the urinary bladder: a clinicopathologic, immunohistochemical, and ultrastructural analysis of eight cases and a review of the literature

Cancer
L PerretL Guillou

Abstract

Heterologous carcinosarcomas of the urinary bladder are rare neoplasms, the histogenesis of which is still disputed. The clinicopathologic, immunohistochemical, and ultrastructural features of eight cases were analyzed. The patients, 5 males and 3 females, had a median age of 70 years. Gross hematuria, dysuria, and urinary tract infections were the main presenting symptoms. Tumors were solitary in all cases and located in the right wall in six cases. Tumor size ranged from 2 to 12 cm (median, 5 cm). Four patients died of disease 2, 6, 17, and 42 months postoperatively, respectively. Microscopically, the tumors consisted mostly of a varied mixture of high grade transitional cell carcinoma with chondrosarcoma, osteosarcoma, rhabdomyosarcoma, and undifferentiated spindle cell (leiomyosarcoma-like) components with occasional transitional features between one component and another. All tumors but one invaded the muscularis propria or the perivesical fatty tissue. Immunohistochemically, keratin expression was observed focally in the sarcoma component as well as the carcinoma component. Reactivity for vimentin, desmin, muscle specific actin, and S-100 protein was observed in poorly differentiated areas in addition to the expected posi...Continue Reading

Citations

Aug 21, 2013·Case Reports in Urology·Doğan Atılgan, Yusuf Gençten
Mar 22, 2014·Journal of Cancer Research and Clinical Oncology·Jiong LuNan-Sheng Cheng
Jan 1, 2011·Case Reports in Urology·Christos ZachariadisStavros Touloupidis
Jul 10, 2001·International Journal of Urology : Official Journal of the Japanese Urological Association·Y S GürbüzO Dillioglugil
Jan 19, 2008·Journal of Cutaneous Pathology·Enrique PobletDolores C García-Olmo
Nov 17, 2009·Histopathology·Jonathan H Shanks, Kenneth A Iczkowski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinosarcoma

Carcinosarcoma is a malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. Discover the latest research on carcinosarcoma here.