Primary High-Grade Non-Muscle-Invasive Bladder Cancer: High NFκB Expression in Tumor Specimens Distinguishes Patients Who are at Risk for Disease Progression

Pathology Oncology Research : POR
Lampros MitrakasVasilios Tzortzis

Abstract

To investigate the potential prognostic role of NFκB expression in primary high-grade non-muscle-invasive bladder cancer. Patients with primary high-grade non-muscle-invasive bladder cancer who received induction and maintenance BCG therapy were retrospectively included. Recurrence and progression were histologically proven. Intensity and extent of immunochemistry were assessed. The final evaluation of the NFκB staining was done by combining intensity and extent as ΄΄product΄΄ and expressing it as ΄΄low NFκΒ expression΄΄ or ΄΄high NFκB expression΄΄. Epidemiological, pathological, clinical parameters and NFκB expression were statistically analyzed for recurrence (REC), progression (PR), recurrence-free survival (RFS) and progression-free survival (PFS). NFκB is significantly associated with disease progression (p < 0,001 in univariate analysis and p = 0,001, Odds Ratio = 14,484, 95% Confidence Interval = 3187-65,821 in multivariate analysis), but not with recurrence. The median value of NFκB expression as ΄΄product΄΄ is significantly higher for the patients with progression in comparison to patients with recurrence only (p = 0,003) and patients without recurrence or progression (p = 0,001). Patients' age is significantly associa...Continue Reading

References

May 23, 1998·Annual Review of Immunology·S GhoshE B Kopp
Jul 12, 2002·The Prostate·Junghan SuhArnold B Rabson
Jul 17, 2004·Neoplasia : an International Journal for Oncology Research·Sanjeev ShuklaSanjay Gupta
Apr 13, 2007·Virchows Archiv : an International Journal of Pathology·Georgia LevidouEfstratios Patsouris
Jan 12, 2008·Virchows Archiv : an International Journal of Pathology·Georgia LevidouEfstratios Patsouris
Jan 1, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ioannis ZachosAthanasios G Papavassiliou
Jun 22, 2016·European Urology·Marko BabjukRichard Zigeuner

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Citations

Apr 2, 2020·Expert Review of Molecular Diagnostics·Charles Emmanuel Jebaraj WalterHatem Zayed
Aug 25, 2019·Cancers·Brittney S Harrington, Christina M Annunziata
Jul 22, 2021·Archivio italiano di urologia, andrologia : organo ufficiale [di] Società italiana di ecografia urologica e nefrologica·Lampros MitrakasChristos Papandreou

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Methods Mentioned

BETA
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