Primary histologic diagnosis using automated whole slide imaging: a validation study.

BMC Clinical Pathology
John R GilbertsonAnil V Parwani

Abstract

Only prototypes 5 years ago, high-speed, automated whole slide imaging (WSI) systems (also called digital slide systems, virtual microscopes or wide field imagers) are becoming increasingly capable and robust. Modern devices can capture a slide in 5 minutes at spatial sampling periods of less than 0.5 micron/pixel. The capacity to rapidly digitize large numbers of slides should eventually have a profound, positive impact on pathology. It is important, however, that pathologists validate these systems during development, not only to identify their limitations but to guide their evolution. Three pathologists fully signed out 25 cases representing 31 parts. The laboratory information system was used to simulate real-world sign-out conditions including entering a full diagnostic field and comment (when appropriate) and ordering special stains and recuts. For each case, discrepancies between diagnoses were documented by committee and a "consensus" report was formed and then compared with the microscope-based, sign-out report from the clinical archive. In 17 of 25 cases there were no discrepancies between the individual study pathologist reports. In 8 of the remaining cases, there were 12 discrepancies, including 3 in which image qua...Continue Reading

References

Jul 25, 2000·Telemedicine Journal : the Official Journal of the American Telemedicine Association·B E DunnR S Weinstein
Mar 1, 1997·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·D J ForanI Marsic
May 8, 2002·Pathology Oncology Research : POR·Péter GombásLászló Hegyi
Aug 22, 2002·Virchows Archiv : an International Journal of Pathology·F DemichelisS Forti
Nov 14, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Keith J KaplanRenata B Greenspan
Jul 15, 2003·Journal of Medical Internet Research·Sean S P CostelloDaniel G O'Shea
Nov 25, 2003·The Anatomical Record. Part B, the New Anatomist·Charles A BlakeClarke F Millette
Oct 8, 2004·The Journal of Pathology·Rakesh K KumarDenis Wakefield
Dec 8, 2004·Acta Cytologica·MariBeth GagnonRhonda Whalen
Apr 23, 2005·BMC Medical Informatics and Decision Making·Dan J JohnstonDaniel G O'Shea

❮ Previous
Next ❯

Citations

Aug 16, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Devon S Chabot-RichardsKristin E Hunt
Aug 30, 2008·Telemedicine Journal and E-health : the Official Journal of the American Telemedicine Association·Daniele GiansantiMaria Rosaria Giovagnoli
Aug 5, 2008·Diagnostic Pathology·John Gilbertson, Yukako Yagi
Aug 5, 2008·Diagnostic Pathology·Essam Ayad, Francesco Sicurello
Aug 5, 2008·Diagnostic Pathology·Marcial García RojoJose Sacristán
Aug 5, 2008·Diagnostic Pathology·Roberto MencarelliAlessio Gasparetto
Apr 22, 2011·Diagnostic Pathology·Christel DanielVincenzo Della Mea
Dec 15, 2012·Diagnostic Pathology·Ikunori NakayamaTakashi Sawai
Oct 2, 2012·Journal of Pathology Informatics·Dorina GuiSarah Dry
Oct 2, 2012·Journal of Pathology Informatics·David S McClintockJohn R Gilbertson
Sep 3, 2011·Journal of Pathology Informatics·Liron PantanowitzTerence J Colgan
Oct 5, 2011·Journal of Pathology Informatics·Richard R McKayMichael C Montalto
Oct 5, 2011·Journal of Pathology Informatics·Mike IsaacsJohn D Pfeifer
May 1, 2012·Archives of Pathology & Laboratory Medicine·Brad KellerMarios A Gavrielides
Jan 18, 2013·Archives of Pathology & Laboratory Medicine·Thomas W BauerWalter H Henricks
Apr 3, 2013·Archives of Pathology & Laboratory Medicine·Pawel MrozPiotr Kulesza
Nov 20, 2012·Annual Review of Pathology·Farzad GhaznaviMichael Feldman
Nov 13, 2008·Expert Review of Molecular Diagnostics·Laoighse MulraneWilliam M Gallagher
Oct 1, 2008·Expert Opinion on Medical Diagnostics·Waqas AminAnil V Parwani
May 23, 2015·Cancer Biology & Therapy·Smrithi RajendiranJamboor K Vishwanatha
Nov 12, 2014·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Michael A ArnoldThomas Barr
May 18, 2012·Human Pathology·W Scott CampbellSteven H Hinrichs
Jul 12, 2014·IEEE Journal of Biomedical and Health Informatics·Alessandro Gherardi, Alessandro Bevilacqua
Mar 18, 2009·Brain Pathology·Miguel Guzman, Alexander R Judkins
Jun 21, 2013·Pathology International·Tokiya AbeMichiie Sakamoto
May 23, 2013·Histopathology·Rachel S van der PostMarius Nap
May 11, 2016·Journal of Clinical Pathology·Shaimaa Al-JanabiMehdi Jiwa
Jul 12, 2016·Archives of Pathology & Laboratory Medicine·Edward GoacherDarren Treanor
Sep 12, 2009·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Viktor Sebestyén VargaBéla Molnár
Mar 29, 2014·Pathology, Research and Practice·Silvia RibbackFrank Dombrowski
Apr 26, 2017·Archives of Pathology & Laboratory Medicine·Andrew J EvansLiron Pantanowitz
Dec 21, 2006·Toxicologic Pathology·Fred R Dee
Oct 17, 2006·International Journal of Surgical Pathology·Marcial García RojoManuel Carbajo Vicente
May 4, 2017·Archives of Pathology & Laboratory Medicine·Bethany J WilliamsDarren Treanor

❮ Previous
Next ❯

Methods Mentioned

BETA
Biopsy

Software Mentioned

IIS
ImageScope
Windows Server
Aperio Image Server

Related Feeds

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Related Papers

Rinsho byori. The Japanese journal of clinical pathology
Tatsusuke SatoTerumasa Takamatsu
Journal of Pathology Informatics
Richard R McKayMichael Montalto
Studies in Health Technology and Informatics
Yukako YagiDavid N Louis
© 2022 Meta ULC. All rights reserved