Primary human immunodeficiency virus type 1 (HIV-1) infection during HIV-1 Gag vaccination

Journal of Virology
Arumugam BalamuruganOtto O Yang

Abstract

Vaccination for human immunodeficiency virus type 1 (HIV-1) remains an elusive goal. Whether an unsuccessful vaccine might not only fail to provoke detectable immune responses but also could actually interfere with subsequent natural immunity upon HIV-1 infection is unknown. We performed detailed assessment of an HIV-1 gag DNA vaccine recipient (subject 00015) who was previously uninfected but sustained HIV-1 infection before completing a vaccination trial and another contemporaneously acutely infected individual (subject 00016) with the same strain of HIV-1. Subject 00015 received the vaccine at weeks 0, 4, and 8 and was found to have been acutely HIV-1 infected around the time of the third vaccination. Subject 00016 was a previously HIV-1-seronegative sexual contact who had symptoms of acute HIV-1 infection approximately 2 weeks earlier than subject 00015 and demonstrated subsequent seroconversion. Both individuals reached an unusually low level of chronic viremia (<1,000 copies/ml) without treatment. Subject 00015 had no detectable HIV-1-specific cytotoxic T-lymphocyte (CTL) responses until a borderline response was noted at the time of the third vaccination. The magnitude and breadth of Gag-specific CTL responses in subject...Continue Reading

References

Oct 25, 2002·AIDS Research and Human Retroviruses·Otto O YangJanis V Giorgi
Jan 28, 2003·Trends in Immunology·Otto O Yang
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Beth D JamiesonSteven Wolinsky
Mar 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael R BettsGuido Ferrari
Nov 17, 2006·The Journal of Infectious Diseases·Barney S GrahamUNKNOWN Vaccine Research Center 004 Study Team
May 18, 2007·The New England Journal of Medicine·Margaret I Johnston, Anthony S Fauci

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