PMID: 7029444Nov 1, 1981Paper

Primary hyperinsulinemia reduces surface active material flux in tracheal fluid of fetal lambs

Pediatric Research
D WarburtonA C Platzker

Abstract

We sought to test the hypothesis that hyperinsulinemia per se alters the flux of surface active material (SAM) into tracheal fluid by continuously infusing insulin (0.24 +/- 0.04 units/kg/hr, mean +/- S.E.) from 112 through 135 days gestation into five chronically catheterised fetal lambs, from which tracheal fluid could be collected. Serum insulin levels in these fetuses (95 +/- 10 microunits/ml) were greater than in five chronically catheterised control fetuses of the same gestational age (10 +/- 1 microunits/ml, P less than 0.001) and in the mothers (38 +/- 6 microunits/ml, P less than 0.001). Serum glucose levels in the insulin-treated fetuses (10 +/- 1 mg/dl) were lower than in the control fetuses (19 +/- 1 mg/dl, P less than 0.001) and in the mothers (60 +/- 3 mg/dl, P less than 0.001). Arterial blood gases (pH 7.37 +/- 0.01, PO2 23.3 +/- 0.05 mm Hg, PCO2 41.5 +/- 0.9 mm Hg) and hematocrit (33 + 1% at 127 days gestation and 31 +/- 1% at 135 days gestation) in the insulin treated fetuses were not different from the controls. SAM flux into the tracheal fluid of the insulin-treated fetuses was 1 microgram/kg/hr, coefficient of variation 373%. This was lower than SAM flux in the control fetuses (26 micrograms/kg/hr, coefficie...Continue Reading

Citations

Mar 1, 1983·The Journal of Clinical Investigation·D Warburton
Jul 6, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Erin V McGillickSandra Orgeig
Apr 2, 2004·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Eyal SivanReuven Achiron
Jun 9, 1988·Biochimica Et Biophysica Acta·M Post, L M van Golde

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