Primary hyperparathyroidism due to ectopic parathyroid adenoma in an adolescent: a case report and review of the literature

Endocrine
Xiangli LiuWenya Li

Abstract

Primary hyperparathyroidism (PHPT) is a common endocrine disorder and is usually diagnosed in adults. PHPT due to ectopic parathyroid adenoma in adolescents is rare. We describe the case of a 15-year-old boy with PHPT due to ectopic parathyroid adenoma. A review of the literature of PHPT in adolescents was performed, focusing on etiology, clinical presentation, preoperative localization methods, pathology, and treatment. The patient was successfully treated with surgery and was followed up for 5 years with no signs or symptoms of hyperparathyroidism. By reviewing the literature, only seven cases of PHPT associated with ectopic parathyroid lesions in adolescents have been reported. Parathyroidectomy is the only known curative treatment. Accurate preoperative localization of the target lesion is critical. This study should raise awareness of the diagnosis and treatment of PHPT due to ectopic parathyroid adenoma/carcinoma in adolescents.

References

Jan 1, 1996·Journal of Computer Assisted Tomography·R SolerI Cao
Mar 1, 2005·The Annals of Thoracic Surgery·Thomas J Birdas, Robert J Keenan
Jul 22, 2005·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·UNKNOWN AACE/AAES Task Force on Primary Hyperparathyroidism
Aug 19, 2007·Lancet·Antonio Sitges-Serra, Anders Bergenfelz
Aug 15, 2008·International Journal of Surgical Pathology·Alberto RighiJames Mize
May 28, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Elif HindiéUNKNOWN Parathyroid Task Group of the EANM
May 30, 2009·Journal of the American College of Surgeons·Glenda G CallenderNancy D Perrier
Jul 15, 2009·Lancet·William D Fraser
Mar 11, 2010·Expert Review of Anticancer Therapy·Daniel S Levine, Sam M Wiseman
Feb 14, 2012·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·C-C LiJ Ouyang
Mar 14, 2014·The Lancet. Diabetes & Endocrinology·David P MacfarlaneGraham P Leese
Jun 21, 2014·Annals of Nuclear Medicine·Ana Koljević MarkovićAngelika Bischof Delaloye
Jul 9, 2014·Obstetrics and Gynecology·Antonio F SaadMaged M Costantine
Aug 13, 2015·Annals of the Royal College of Surgeons of England·Jesse HuR Parameswaran
Jan 31, 2017·Endocrinology and Metabolism Clinics of North America·Kyle A Zanocco, Michael W Yeh
May 12, 2017·Radiology Case Reports·Islam A Shehata ElhelfJoan Maley
Jun 29, 2017·JAMA Surgery·Antonia E StephenRichard A Hodin
Sep 9, 2017·Nature Reviews. Endocrinology·Marcella D Walker, Shonni J Silverberg
Sep 20, 2017·Lancet·John P BilezikianNatalie E Cusano

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Citations

Sep 3, 2020·Annals of Pediatric Endocrinology & Metabolism·Youngseok SeoHo-Seong Kim
Oct 27, 2020·The Journal of International Medical Research·Yu Wang, Jie Liu
Apr 30, 2021·AACE Clinical Case Reports·Myrto Eleni FlokasLevon Agdere

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