Abstract
To provide an up-to-date review of primary hyperparathyroidism (HPT) as a complication of pregnancy. We discuss the initial manifestations of primary HPT in pregnant patients, the diagnosis, the differential diagnosis of hypercalcemia, and the recommended treatment strategies. In the nonpregnant state, 50 to 80% of patients with primary HPT are asymptomatic. In contrast, pregnant patients with primary HPT have a wide variety of symptoms and findings: gastrointestinal symptoms (nausea, vomiting, and anorexia), weakness and fatigue, headaches and confusion, nephrolithiasis, bone disease, pancreatitis, urinary tract infection, and hypertension. Occasionally, neonatal hypocalcemia is the initial manifestation of maternal HPT. Diagnosis of primary HPT during pregnancy is dependent on the clinical history and laboratory findings. In general, management of maternal primary HPT during pregnancy should be individualized and based on the patient's symptoms, general medical condition, severity of disease, and gestational stage at the time of diagnosis. If HPT is diagnosed during the first two trimesters, surgical intervention is the treatment of choice. Although uncommon, HPT during pregnancy may be associated with maternal and perinatal ...Continue Reading
References
Apr 1, 1979·American Journal of Obstetrics and Gynecology·R M PitkinG K Hargis
Jun 22, 1979·Science·T K GrayR S Lorenc
Jul 1, 1992·Journal of General Internal Medicine·M J Carella, V V Gossain
May 1, 1991·American Journal of Obstetrics and Gynecology·K SekiI Nagata
Apr 19, 1990·The New England Journal of Medicine·S KhoslaT J Martin
Apr 1, 1990·Clinical Pediatrics·B R Powell, N R Buist
Jul 1, 1990·American Journal of Perinatology·J A KullerJ T Repke
Oct 1, 1988·The Journal of Clinical Endocrinology and Metabolism·O K DavisI Schiff
Aug 1, 1987·British Journal of Obstetrics and Gynaecology·G S MatthiasA Williams
Jun 1, 1987·Clinical Endocrinology·T CundyJ A Kanis
Aug 1, 1986·Journal of Clinical Pathology·C F MonizC H Rodeck
Sep 1, 1986·The American Journal of Medicine·J M GertnerA E Broadus
Jan 1, 1986·Acta Obstetricia Et Gynecologica Scandinavica·B Fabrin, K Eldon
Jun 1, 1972·American Journal of Obstetrics and Gynecology·R C Corlett, D R Mishell
May 1, 1973·Archives of Surgery·O S BetterD Erlik
Sep 1, 1970·The American Journal of the Medical Sciences·D BronskyJ J Barton
Nov 1, 1968·Postgraduate Medical Journal·M A SoyannwoT G Milliken
Jan 4, 1969·British Medical Journal·A D WrightH G Dixon
Feb 3, 1966·The New England Journal of Medicine·H Hartenstein, L I Gardner
May 1, 1983·American Journal of Surgery·D K LoweC G Peterson
Feb 1, 1983·The Journal of Clinical Endocrinology and Metabolism·G S ReddyE Mayer
Apr 1, 1982·Obstetrical & Gynecological Survey·M M ShangoldM C Crenshaw
Feb 4, 1982·The New England Journal of Medicine·S J MarxM Fox
Aug 1, 1981·American Journal of Obstetrics and Gynecology·D ClarkR C Cefalo
Mar 1, 1981·The Journal of Clinical Endocrinology and Metabolism·E Leroyer-AlizonP M Dubois
Mar 1, 1994·The Journal of Clinical Investigation·M R PollakE M Brown
Mar 4, 1993·The New England Journal of Medicine·F LepreT J Martin
Jun 15, 1963·American Journal of Obstetrics and Gynecology·P J WHALLEY
Dec 1, 1964·Annals of Internal Medicine·P HUTCHIN, D M KESSNER
Sep 27, 1962·The New England Journal of Medicine·G D LUDWIG
Dec 1, 1947·American Journal of Surgery·D W PETIT, R L CLARK
Apr 1, 1947·The Journal of Pediatrics·E L PRATTE B D NEUHAUSER
Citations
Nov 30, 2000·Obstetrics and Gynecology·M N MontoroJ H Mestman
Feb 5, 2010·International Journal of Otolaryngology·E KandilB M Jaffe
Sep 2, 2008·The Laryngoscope·Mai Thy TruongMichael Friduss
Jan 29, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ilana ParkesYoel Shufaro
Mar 29, 2019·Clinical Obstetrics and Gynecology·Scott A Sullivan