Primary hyperparathyroidism in multiple endocrine neoplasia type 1: when to perform surgery?

Clinics
Francesca GiustiMaria Luisa Brandi

Abstract

Primary hyperparathyroidism is a common endocrinological disorder. In rare circumstances, it is associated with familial syndromes, such as multiple endocrine neoplasia type 1. This syndrome is caused by a germline mutation in the multiple endocrine neoplasia type 1 gene encoding the tumor-suppressor protein menin. Usually, primary hyperparathyroidism is the initial clinical expression in carriers of multiple endocrine neoplasia type 1 mutations, occurring in more than 90% of patients and appearing at a young age (20-25 years). Multiple endocrine neoplasia type 1/primary hyperparathyroidism is generally accompanied by multiglandular disease, clinically manifesting with hypercalcemia, although it can remain asymptomatic for a long time and consequently not always be recognized early. Surgery is the recommended treatment. The goal of this short review is to discuss the timing of surgery in patients when primary hyperparathyroidism is associated with multiple endocrine neoplasia type 1.

Citations

Sep 14, 2015·Surgical Oncology Clinics of North America·Jeffrey A NortonRobert T Jensen
Jul 27, 2017·Endocrine-related Cancer·Hermine Mohr, Natalia S Pellegata
Aug 5, 2017·Endocrine-related Cancer·Rachel S van LeeuwaardeGerlof D Valk
Jul 28, 2019·Clinical Endocrinology·Madhuni HerathJohn Burgess
Apr 25, 2020·Orphanet Journal of Rare Diseases·Davide MaraghelliMaria Luisa Brandi
Jul 16, 2020·Clinical Rheumatology·Maroua SloumaBassem Louzir
Jul 3, 2019·Frontiers in Endocrinology·Crystal D C Kamilaris, Constantine A Stratakis
Mar 12, 2020·Proceedings of the National Academy of Sciences of the United States of America·Amanda R WasylishenGuillermina Lozano
Dec 15, 2020·Frontiers in Endocrinology·Chiara MelePaolo Marzullo

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Otolaryngologic Clinics of North America
James P MaloneRomesh Khardori
European Journal of Internal Medicine
Grzegorz PiechaAndrzej Więcek
International Journal of Endocrinology
Grzegorz PiechaAndrzej Więcek
© 2021 Meta ULC. All rights reserved