Primary hyperparathyroidism: possible cause of primary hyperaldosteronism in a 60-year-old woman

The Journal of Clinical Endocrinology and Metabolism
A BarkanI Blum

Abstract

Hypertension and hypokalemia were found in a 60-yr-old woman suffering from primary hyperparathyroidism. Laboratory investigations in this patient disclosed 1) elevated levels of plasma aldosterone (PA) which could not be suppressed by a high sodium diet alone or in combination with fludrocortisone (Florinef); 2) a decline of the elevated PA levels after 4 h of ambulation; and 3) low PRA which was unresponsive to stimulation by a low sodium diet coupled with diuretic-induced volume depletion and 4 h of ambulation. These findings were consistent with the diagnosis of primary hyperaldosteronism. Extirpation of a parathyroid adenoma reduced the patient's serum calcium level to normal, and subsequently, a normalization of her blood pressure, serum electrolytes, PA, and PRA were observed. On the basis of these data is is suggested that in this case hyperaldosteronism may have been caused directly or indirectly by primary hyperparathyroidism.

Citations

Jun 1, 1982·Metabolism: Clinical and Experimental·A GangulyC C Johnston
Feb 16, 2012·Cardiovascular Research·Andreas TomaschitzStefan Pilz
Mar 1, 1981·Postgraduate Medical Journal·D V Hamilton, J S Pryor
Apr 4, 2014·Current Opinion in Endocrinology, Diabetes, and Obesity·Jenifer M Brown, Anand Vaidya
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·D H Ellison, D A McCarron
Jan 30, 2015·Journal of Human Hypertension·A VaidyaJ S Williams
Oct 30, 2010·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Kavita NyalakondaFaramarz Ismail-Beigi
Jun 22, 2014·American Journal of Hypertension·Katrina ChauClifford Chan-Yan
Dec 5, 2018·Endocrinology and Metabolism·Jung Soo LimYumie Rhee
Jan 16, 2014·The Journal of Clinical Endocrinology and Metabolism·Evelyn FischerMartin Reincke
Oct 21, 2011·The Journal of Clinical Endocrinology and Metabolism·Stefan PilzAndreas Tomaschitz
May 22, 2019·Nutrients·Cecilia Villa-EtchegoyenGabriela Cormick
Oct 27, 2020·Frontiers in Endocrinology·Shaomin ShiTao Chen
Sep 12, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Guido ZavattaValentina Vicennati

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