PMID: 6411394Aug 1, 1983Paper

Primary hypothyroidism of childhood: evaluation of the hypothalamic-pituitary gonadal axis before and during L-thyroxine replacement

Clinical Endocrinology
J A Kugler, C A Huseman

Abstract

Hypothyroidism is frequently associated with abnormal sexual development. To determine the longitudinal influence of thyroxine replacement on the hypothalamic pituitary gonadal axis, we studied five prepubertal hypothyroid girls and two boys before, and all the girls six weeks and one year after, thyroxine replacement. All girls showed significantly elevated basal gonadotrophin concentrations before treatment. Following one year of therapy, despite all girls having begun puberty, basal gonadotrophin concentrations were significantly decreased in the four euthyroid girls as compared with our normal pubertal girls. The fifth girl studied at one year was hypothyroid at the time of testing and her gonadotrophin values were increased even above previous basal values. Pretreatment serum TSH values inversely correlated with maximum pretreatment incremental LH (r = -0.54) and FSH (r = -0.52) responses to LHRH. Serum TSH values directly correlated with PRL concentrations (r = +0.82). Of the two hypothyroid boys evaluated, Patient 1 was mildly hypothyroid and showed normal prepubertal basal LH, FSH, testosterone and low normal LHRH responsiveness. Patient 2, who was more severely hypothyroid, had elevated basal gonadotrophin secretion an...Continue Reading

References

Jan 1, 1978·The Journal of Pediatrics·Z S HemadyS Najjar
May 1, 1975·The Journal of Clinical Endocrinology and Metabolism·M M VarmaC J Migeon
Jun 1, 1972·The Journal of Clinical Endocrinology and Metabolism·I J Chopra
Sep 1, 1965·The Journal of Clinical Endocrinology and Metabolism·W D OdellW E Paul
Aug 1, 1973·Metabolism: Clinical and Experimental·H G Friesen
Jul 1, 1971·Steroids·C H Wu, L E Lundy
Jun 1, 1969·Archives of Disease in Childhood·W A Marshall, J M Tanner
Feb 1, 1967·The Journal of Clinical Endocrinology and Metabolism·A R Midgley
Aug 1, 1980·The Journal of Pediatrics·A W LuckyN Roche-Bender
Feb 4, 1905·British Medical Journal·F W Kendle

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Citations

Aug 1, 1988·Baillière's Clinical Endocrinology and Metabolism·J E Silva
Jul 1, 1991·Journal of Endocrinological Investigation·W H HoffmanC L Burek
Mar 1, 1988·The Journal of Pediatrics·M Castro-MagañaB Fuentes
Feb 4, 2010·Arquivos brasileiros de endocrinologia e metabologia·Simone Magagnin WajnerAna Luiza Maia
Sep 30, 2015·The Journal of Endocrinology·Nadia SchoenmakersMehul T Dattani
May 9, 2012·Anatomy Research International·Kamal Sarma, J Devi

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