Primary IgA nephropathy in elderly patients

Nephrology
Wisit CheungpasitpornQi Qian

Abstract

Data on clinicopathological features, treatment and outcomes of IgA nephropathy (IgAN) in elderly patients are limited. Native kidney biopsies with a pathological diagnosis of IgAN (n = 1084) from Mayo Clinic Rochester in the years 1994-2013 were examined. After exclusion of the secondary IgAN, 45 elderly IgAN patients (age ≥65 years) were identified. One hundred sixty-two younger adults (age 18-64 years) with IgAN were randomly selected for comparison. Compared with younger adults, elderly patients showed a higher rate of chronic hypertension (62.2 vs 27.2%), higher pulse pressures (65 ± 17 vs 51 ± 15 mmHg), requiring greater number of antihypertensive medications (2.5 ± 1.2 vs 1.7 ± 0.7) and lower blood haemoglobin (11.1 ± 2.3 vs 12.7 ± 2.1 g/dL) at time of kidney biopsy, all P < 0.001. Pathologically, elderly kidneys showed a higher degree of tubulointerstitial fibrosis (P = 0.04) and vascular sclerosis (P < 0.001). Treatments (including the use of angiotensin-converting enzyme inhibitor (ACEI) inhibitor, angiotensin II receptor blocker (ARB) and immunosuppressants) were similar in the two cohorts. Elderly patients had more end-stage renal disease at 6 months (HR 5.51; 95% CI 1.46-22.3, P = 0.01) and higher 6-month and 5-yea...Continue Reading

References

Feb 21, 1991·The American Journal of Medicine·J G Porush, M Weinberger
Nov 1, 1985·Artificial Organs·R CoppoG Piccoli
Jan 1, 1985·American Journal of Nephrology·C K Abrass
Nov 1, 1994·Journal of Clinical Epidemiology·M CharlsonJ Gold
Oct 1, 1993·American Journal of Clinical Pathology·D M Wilson, R L Anderson
Jun 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·L FrimatM Kessler
Aug 5, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Colin C GeddesDaniel C Cattran
Aug 26, 2004·Kidney International·Francisco RiveraUNKNOWN Spanish Registry of Glomerulonephritis
Feb 18, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Luc NoyezFreek W A Verheugt
Apr 25, 2006·Clinical Nephrology·G FerroF Pizzarelli
Sep 2, 2008·Cleveland Clinic Journal of Medicine·Richard J Glassock
Sep 12, 2008·Interactive Cardiovascular and Thoracic Surgery·Jacobo SilvaJosé E Rodríguez
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Jun 12, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Masashi GotoYasuhiko Tomino
Jul 3, 2009·Kidney International·UNKNOWN Working Group of the International IgA Nephropathy Network and the Renal Pathology SocietyHong Zhang
Jul 3, 2009·Kidney International·UNKNOWN Working Group of the International IgA Nephropathy Network and the Renal Pathology SocietyHong Zhang
Sep 16, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Seung Hyeok HanShin-Wook Kang
Jan 25, 2011·Journal of the American Society of Nephrology : JASN·François BerthouxLise Thibaudin
Jun 15, 2011·Renal Failure·Tayebeh SoleymanianBehrooz Broomand
Nov 19, 2011·Journal of the American Society of Nephrology : JASN·Annelies E BerdenUNKNOWN European Vasculitis Society
Aug 21, 2012·Journal of the American Society of Nephrology : JASN·Francois BerthouxJan Novak
Oct 12, 2012·Clinical and Experimental Nephrology·Hitoshi YokoyamaUNKNOWN Committee for the Standardization of Renal Pathological Diagnosis and for Renal Biopsy and Disease Registry of the Japanese
Jun 21, 2013·The New England Journal of Medicine·Robert J Wyatt, Bruce A Julian
Sep 12, 2013·American Journal of Nephrology·Zhi-Yu DuanXiang-Mei Chen

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Citations

Nov 21, 2017·Nephrology·Jing LinQi Qian
Jul 18, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Angel M SevillanoUNKNOWN Spanish Group for the Study of Glomerular Diseases (GLOSEN)

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