Primary Immunodeficiency and Cancer Predisposition Revisited: Embedding Two Closely Related Concepts Into an Integrative Conceptual Framework

Frontiers in Immunology
Oskar A Haas

Abstract

Common understanding suggests that the normal function of a "healthy" immune system safe-guards and protects against the development of malignancies, whereas a genetically impaired one might increase the likelihood of their manifestation. This view is primarily based on and apparently supported by an increased incidence of such diseases in patients with specific forms of immunodeficiencies that are caused by high penetrant gene defects. As I will review and discuss herein, such constellations merely represent the tip of an iceberg. The overall situation is by far more varied and complex, especially if one takes into account the growing difficulties to define what actually constitutes an immunodeficiency and what defines a cancer predisposition. The enormous advances in genome sequencing, in bioinformatic analyses and in the functional in vitro and in vivo assessment of novel findings together with the availability of large databases provide us with a wealth of information that steadily increases the number of sequence variants that concur with clinically more or less recognizable immunological problems and their consequences. Since many of the newly identified hard-core defects are exceedingly rare, their tumor predisposing eff...Continue Reading

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Citations

Jul 6, 2019·Frontiers in Microbiology·Yuxi WenHongbo Chen
Mar 13, 2020·European Journal of Pediatrics·Samuele RenziMichaela Cada
Aug 28, 2020·Frontiers in Immunology·Kissy Guevara-HoyerSilvia Sánchez-Ramón
Jun 4, 2020·Current Opinion in Hematology·Kevin Z ChenCheng-Kui Qu
Jan 20, 2021·International Reviews of Immunology·Maryam MohtashamiReza Yazdani
Feb 16, 2021·Frontiers in Oncology·Jia-An ZhangKun Chen
Nov 12, 2020·Jornal de pediatria·Ekaterini Simões Goudouris
Apr 6, 2021·Current Tissue Microenvironment Reports·Praveen Krishna VeerasubramanianTimothy L Downing
May 5, 2021·Expert Review of Clinical Immunology·Safa Baris, Burcu Kolukisa
Jul 13, 2021·Frontiers in Medicine·Alexandra SchifferliThomas Kühne
Jul 27, 2021·Clinics in Laboratory Medicine·Emily F Mason, Alexandra E Kovach
Aug 3, 2021·Frontiers in Immunology·Eric de SousaMarkus Maeurer

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Methods Mentioned

BETA
MDS

Software Mentioned

TOFT

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