Primary immunoglobulin repertoire development: time and space matter

Current Opinion in Immunology
Alessandra GranatoDuane R Wesemann

Abstract

The primary immunoglobulin repertoire develops via opposing forces of expanding diversification balanced by contracting selection mechanisms. The resulting shape is essential for host health and immune fitness. While the molecular mechanisms of Ig diversification have largely been defined, selection forces shaping emerging Ig repertoires are poorly understood. During lifetime, human and mouse early B cell development occurs at distinct locations-beginning in fetal liver before transferring to bone marrow and spleen by the end of gestation. During an early life window of time, the murine gut lamina propria harbors developing immature B cells in proximity to intestinal contents such as commensal microbes and dietary antigens. Location and timing of early B cell development may thus endow neighboring antigens with primary repertoire-shaping capabilities.

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Citations

Feb 13, 2016·Immunological Reviews·Duncan B SutherlandSidonia Fagarasan
Jun 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Sherry G LinFrederick W Alt
Mar 17, 2018·Innate Immunity·Nailia R KhasbiullinaNicolai V Bovin
Mar 29, 2018·The Journal of Experimental Medicine·Yuezhou ChenDuane R Wesemann
Jan 26, 2017·Frontiers in Immunology·Gonca E KarahanSebastiaan Heidt
Apr 11, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kathy D McCoy, Carolyn A Thomson
Aug 16, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susana MagadanIrene Salinas
Sep 16, 2021·Applied Microbiology and Biotechnology·Paula Matos de BritoJoao Goncalves

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