Primary immunolocalization of androgen target cells in the human anterior cruciate ligament

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
W P HamletG A Finerman

Abstract

To identify androgen target cells in the human anterior cruciate ligament, immunohistochemical localization of the androgen receptor was performed in 31 specimens of the ligament. All of the specimens were obtained at surgery. Seventeen specimens were from women, and 14 were from men: the average age of the patients was 45.2 years (range: 18-78 years). An immunoperoxidase method using monoclonal antibodies to the androgen receptor was employed to identify androgen target cells in the ligament. Consistent staining of the androgen receptor was demonstrable in six specimens obtained from young men 18-24 years old, and equivocal positive staining was seen in two other specimens from young men. No receptors were demonstrated by this method in any of the specimens from women or older men. Androgen receptors were localized to synoviocytes in the synovium and under the synovial lining, fibroblasts in the ligament stroma, and cells lining the blood-vessel walls of the anterior cruciate ligament. The demonstration of androgen receptors in the cells of the anterior cruciate ligament strongly suggests that male sex hormones may have an effect on the structure and composition of this ligament in young men.

References

Feb 1, 1976·Journal of Applied Physiology·D L CostillB Saltin
Nov 1, 1978·The American Journal of Sports Medicine·S Nilsson, A Roaas
Oct 1, 1975·Biology of Reproduction·R T Lohl, H Mohammed
Jan 1, 1990·Gynecologic and Obstetric Investigation·P SmithU Ulmsten
Nov 1, 1990·The Journal of Clinical Endocrinology and Metabolism·C KasperkD Baylink
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A ShimadaL S Miller
Dec 1, 1985·International Journal of Sports Medicine·J GrayR G Davidson
Oct 1, 1971·The American Journal of Physiology·C M TiptonW Mergner
Dec 18, 1974·Biochimica Et Biophysica Acta·K Y Kao, W E Hitt
Sep 1, 1982·The American Journal of Sports Medicine·J A ZeliskoM Porter
Feb 1, 1981·Circulation Research·H C McGill, P J Sheridan
May 1, 1995·Calcified Tissue International·D Vanderschueren, R Bouillon
Dec 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·O LapcíkL Stárka
Jan 1, 1995·World Journal of Urology·M T Story
Jul 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S H LiuJ M Lane
Mar 1, 1980·The Physician and Sportsmedicine·Patricia A Whiteside

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Citations

Jun 22, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J SlauterbeckD M Burchfield
Jan 26, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Sandra J ShultzDavid H Perrin
Dec 14, 2011·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Rose FouladiMehrnaz Geranmayeh
Dec 4, 2003·The Journal of Hand Surgery·Alessia PagnottaFrancesco Greco
Aug 24, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M J FoosD M Hardy
Feb 21, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A PagnottaF Greco
Feb 1, 2006·The Journal of Sports Medicine and Physical Fitness·S J ShultzD H Perrin
Oct 4, 2008·Journal of Athletic Training
Sep 14, 2010·Journal of Athletic Training·Sandra J ShultzSusan M Sigward
Jun 10, 2008·British Journal of Sports Medicine·P RenstromL Engebretsen
Aug 28, 2014·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Lazar StijakBranislav Filipović
May 17, 2014·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Lazar StijakBranislav Filipović
Jan 11, 2005·Osteoarthritis and Cartilage·Alfons S K de HoogeWim B van den Berg
Nov 3, 2016·The Physician and Sportsmedicine·Anne E GoldringMary K Mulcahey
Oct 17, 2012·Journal of Athletic Training·Sandra J ShultzDarin A Padua
Jan 4, 2007·The Journal of Pathology·A J Freemont, J A Hoyland
Mar 26, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Richard M Lovering, William A Romani
Feb 18, 2010·Sports Medicine and Arthroscopy Review·Robert H BrophyBert R Mandelbaum
Oct 27, 2001·The American Journal of the Medical Sciences·J R Slauterbeck, D M Hardy
Dec 5, 2006·The Orthopedic Clinics of North America·James R SlauterbeckDaniel M Hardy

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