Primary infection with dengue or Zika virus does not affect the severity of heterologous secondary infection in macaques

PLoS Pathogens
Meghan BreitbachDavid O'Connor

Abstract

Zika virus (ZIKV) and dengue virus (DENV) are genetically and antigenically related flaviviruses that now co-circulate in much of the tropical and subtropical world. The rapid emergence of ZIKV in the Americas in 2015 and 2016, and its recent associations with Guillain-Barré syndrome, birth defects, and fetal loss have led to the hypothesis that DENV infection induces cross-reactive antibodies that influence the severity of secondary ZIKV infections. It has also been proposed that pre-existing ZIKV immunity could affect DENV pathogenesis. We examined outcomes of secondary ZIKV infections in three rhesus and fifteen cynomolgus macaques, as well as secondary DENV-2 infections in three additional rhesus macaques up to a year post-primary ZIKV infection. Although cross-binding antibodies were detected prior to secondary infection for all animals and cross-neutralizing antibodies were detected for some animals, previous DENV or ZIKV infection had no apparent effect on the clinical course of heterotypic secondary infections in these animals. All animals had asymptomatic infections and, when compared to controls, did not have significantly perturbed hematological parameters. Rhesus macaques infected with DENV-2 approximately one year ...Continue Reading

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Citations

Dec 6, 2019·Journal of Virology·Gage K MorenoDavid H O'Connor
Sep 22, 2019·Nature Communications·Erick X Pérez-GuzmánCarlos A Sariol
May 6, 2020·Nature Microbiology·Theodore C Pierson, Michael S Diamond
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Nov 16, 2020·Tropical Medicine & International Health : TM & IH·Vánio A MugabeGuilherme S Ribeiro
Apr 2, 2021·Journal of Virology·Blake SchouestDaniela Weiskopf
Jun 4, 2021·Frontiers in Immunology·Christina M NewmanDavid H O'Connor
Aug 27, 2021·Nature Reviews. Microbiology·Christina J Megli, Carolyn B Coyne
Sep 24, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Samuel Santos PereiraLuís Carlos de Souza Ferreira

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Methods Mentioned

BETA
blood collection
ELISA
sedation
blood draws
reverse transcription PCR
Assay

Software Mentioned

Bio
GraphPad
Excel
lme4
GraphPad Prism
GraphPad Preference intervalSM
R Studio
SAS
Plex Manager

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