Primary Invasive Squamous Cell Carcinoma of the Nipple

Case Reports in Pathology
Avani A Pendse, Siobhan M O'Connor

Abstract

Squamous cell carcinoma is one of the most common cutaneous cancers; however, primary squamous cell carcinoma of the nipple is extremely rare. Among the few reported cases, the majority have occurred in older women with rare cases seen in younger women and male patients. Our patient presented with an exophytic mass of the right nipple while pregnant. A superficial biopsy was reviewed at an outside institution and then at our institution and diagnosed as squamous papilloma and then as hyperkeratosis of the nipple, respectively. The subsequent excisional biopsy revealed multiple nests of tumor cells extending into the dermis with associated chronic inflammatory infiltrate, and the lesion was diagnosed as a primary invasive squamous cell carcinoma of the nipple. Following that, a wide local excision of the excision site and sampling of the regional lymph nodes were negative for carcinoma. Due to the rarity of this diagnosis, it is not known whether prognosis and response to therapy differ from cutaneous squamous cell carcinoma at other sites. Therefore, risk stratification and therapy have been based on those for cutaneous squamous cell carcinoma.

References

Dec 1, 1992·The British Journal of Dermatology·T J StephensonS S Bleehen
Dec 1, 1994·Human Pathology·V S VenkataseshanR V Hutter
Mar 29, 2001·The New England Journal of Medicine·M Alam, D Ratner
Feb 28, 2002·Journal of the American Academy of Dermatology·Can BaykalMurat Alper
Feb 8, 2005·The Breast : Official Journal of the European Society of Mastology·P T BrookesT Usman
Mar 21, 2009·Clinical Breast Cancer·Ruby Sharma, Malini Iyer
Jun 23, 2010·Journal of Medical Case Reports·Catherine E Loveland-JonesKathleen J Reilly
Apr 26, 2013·JAMA Dermatology·H William HigginsGeorge Kroumpouzos
May 30, 2013·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Stratos S SofosM I James
Dec 11, 2014·Indian Journal of Cancer·S Pragati UpashamS Sudhamani

❮ Previous
Next ❯

Citations

Jun 6, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·E CinottiP Rubegni
Jul 22, 2018·Case Reports in Dermatological Medicine·Araya ZaesimShaun A Price

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
dissection

Software Mentioned

Keflex

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.