Primary lung carcinoma with signet-ring cell carcinoma components: clinicopathological analysis of 39 cases

The American Journal of Surgical Pathology
Koji TsutaA Ochiai

Abstract

The clinical and histologic profiles of primary lung carcinomas with signet-ring cell carcinoma (SRCC) components were analyzed. The SRCC components were seen in 39 cases (1.5%) of 2640 cases of surgically resected primary lung carcinomas. The patients' mean age was 54.6 years (range, 32-76 years), and the male-to-female ratio was 1.16:1.00. Twenty-six patients (66.7%) were smokers. The SRCC component was seen as part of an adenocarcinoma in 36 cases (acinar, 27 cases; mixed bronchioloalveolar and acinar, 9 cases) and as part of an adenosquamous cell carcinoma in 2 cases; one lesion consisted of only SRCC cells. The morphologic appearance of cancer nests containing SRCC was classified into three patterns: solid, tubuloacinar, and discohesive. Each case was composed of a varying proportion of these three patterns. The carcinomas with SRCC components were divided into two groups, according to those in which the SRCC component occupied <50% of the lesion (L-SRCC; n = 20) and those in which the SRCC component occupied > or = 50% of the lesion (H-SRCC; n = 19). The frequencies of blood vessel invasion, lymph vessel invasion, and lymph node metastasis were significantly higher in the H-SRCC group than in 1634 adenocarcinoma, and aden...Continue Reading

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Citations

Apr 13, 2006·Virchows Archiv : an International Journal of Pathology·Tsuyoshi IshiharaSaburo Onishi
Jun 27, 2008·The American Journal of Surgical Pathology·Kazuhiro SentaniWataru Yasui
Jun 27, 2008·The American Journal of Surgical Pathology·Thomas M Ulbright, Robert H Young
Apr 29, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Koji TsutaRyoji Kushima
Mar 9, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bryan N Coffing, Megan S Lim
Nov 30, 2016·The American Journal of Dermatopathology·Alan S Boyd
Sep 13, 2012·Journal of Korean Medical Science·Lucia KimYoung Chae Chu
Dec 17, 2008·Diagnostic Cytopathology·Ni JinDavid Wolfson
Jul 10, 2014·The American Journal of Surgical Pathology·Jennifer M BolandEunhee S Yi
Jul 10, 2019·Case Reports in Obstetrics and Gynecology·Sabine DanzingerHeinz Kölbl
Aug 24, 2017·Diagnostic Cytopathology·K MiyataM Sawabe
May 26, 2018·The Journal of the American Osteopathic Association·Michael CorviniUyen Nguyen
Dec 7, 2019·South Asian Journal of Cancer·Varun RajpalDeepak Talwar
Apr 21, 2016·Diagnostic Cytopathology·Archana George VallonthaielSudheer Arava
Apr 22, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mariyo Rokutan-KurataHironori Haga
Feb 18, 2021·Thoracic Cancer·Alberto TestoriUgo Cioffi
Dec 20, 2021·Clinical and Experimental Dermatology·Pallavi HegdeRaghavendra Rao

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