Primary Malignant Lymphoma of the Trigeminal Nerve: Case Report and Literature Review

World Neurosurgery
Toshihiro OgiwaraKazuhiro Hongo

Abstract

Primary lymphomas of the cranial nerves are extremely rare except for optic nerve lymphoma, and it is difficult to make a correct diagnosis in the initial stage. Here, we report a case of primary malignant lymphoma of the left trigeminal nerve that presented as trigeminal nerve disorder. A 47-year-old man presented with aggravating left facial pain and hypesthesia within all three divisions of the trigeminal nerve. Magnetic resonance imaging (MRI) revealed a swollen left trigeminal nerve with gadolinium homogenous enhancement. An open biopsy had to be taken from two different locations of the tumor via the lateral suboccipital approach followed by subtemporal approach because adequate specimen volume was not obtained for definitive diagnosis at the first surgery. Histopathological examinations with flow cytometric analysis revealed diffuse large B cell lymphoma. Chemotherapy followed by whole-brain radiation therapy was effective. No recurrence was observed during a 15-month follow-up period. This is a rare clinical presentation of malignant lymphoma of the trigeminal nerve. It is difficult to establish a correct diagnosis of trigeminal nerve lesions during the initial stages without biopsy. Therefore it is important that a suf...Continue Reading

References

Apr 24, 1999·Acta neurochirurgica·J DomínguezP A Gómez
Jun 7, 2006·British Journal of Neurosurgery·A Celal IplikciogluD Ozcan
Sep 1, 2009·Rinshō shinkeigaku = Clinical neurology·Miho AkazaHidehiro Mizusawa
Sep 10, 2013·British Journal of Neurosurgery·Chandrashan PereraAugusto Gonzalvo
Jan 5, 2014·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Andrew S JackJ Max Findlay

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Citations

Oct 4, 2015·World Neurosurgery·Toshihiro OgiwaraKazuhiro Hongo
Feb 10, 2016·World Neurosurgery·Josue Avecillas-ChasinIssa Subhi-Issa
Aug 18, 2018·BMJ Case Reports·Isaac PhangWilliam Taylor
Aug 7, 2019·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Andrew J ArifinS Danielle MacNeil

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