Primary malignant melanoma of the cervix: report of a case

Archives of Gynecology and Obstetrics
Gülseren YücesoyIzzet Yucesoy

Abstract

To present a case of primary malignant melanoma of the cervix. The patient was admitted with the complaint of vaginal bleeding. Gynecological examination revealed a dark, papillary mass on the posterior lip of the cervix. Histopathology showed a malignant neoplasm with increased vascularity, indicating the possibility of a primary uterine cervical melanoma. Diagnosis of malignant melanoma was confirmed with immunohistochemistry, which showed diffuse positive reactions for S-100 protein and HBM-45, with no reaction for epithelial markers, namely cytokeratin AE1/AE3 and epithelial membrane antigen. An extensive search for a melanotic lesion in skin and in uveal tract was performed to verify the distinct site of melanoma. The tumor was stage IB1 according to the International Federation of Gynecology and Obstetrics classification.The patient underwent radical Wertheim-Meigs hysterectomy, bilateral salpingo-oopherectomy, and retroperitoneal pelvic lympadenectomy. Radiotherapy or chemotherapy was not performed in the postoperative period. She is now free of the disease 10 months after the operation. Primary malignant melanoma of the cervix is a rare cervical malignancy.

References

Apr 1, 1976·Obstetrical & Gynecological Survey·C P Morrow, P J DiSaia
Jun 1, 1990·Gynecologic Oncology·E PodczaskiR Mortel
Nov 1, 1990·Obstetrical & Gynecological Survey·J T SantosoJ Ray
Dec 1, 1971·American Journal of Obstetrics and Gynecology·H W JonesE L Makowski
Oct 1, 1966·American Journal of Clinical Pathology·H J Norris, H B Taylor
Jul 2, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·K C ClarkM R Hapke
Jun 28, 2003·Cytopathology : Official Journal of the British Society for Clinical Cytology·S GuptaS Jain
Oct 3, 2006·Journal of Lower Genital Tract Disease·Azam S MousaviMansour Jamali

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Citations

Apr 26, 2011·Critical Reviews in Oncology/hematology·Sara PuscedduRoberto Buzzoni
Apr 23, 2017·BMJ Case Reports·Ivo JuliãoAna Raimundo
Feb 16, 2017·Case Reports in Obstetrics and Gynecology·Tomoko NoguchiKazuhiko Ino

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