Primary malignant melanoma of the uterine cervix treated with pembrolizumab after radical surgery: a case report and literature review

Obstetrics & Gynecology Science
Myeong Seon KimByoung-Gie Kim

Abstract

Malignant melanoma of the genital tract is a rare disease that is usually diagnosed by chance. When a definite diagnosis is delayed, the prognosis is very poor without standardized treatment. Herein, we describe a 40-year-old patient who presented with a history of bloody vaginal discharge for 7 months. Gynecological examination showed an exophytic, hard and pigmented cervical mass involving the upper vagina. The patient was diagnosed with cervical melanoma after a punch biopsy and underwent a radical hysterectomy, upper vaginectomy, bilateral salpingo-oophorectomy and pelvic lymphadenectomy. After surgeries, the patient underwent 2-cycles of adjuvant immunotherapy with pembrolizumab, but died within 8 months. In this report, treatment with pembrolizumab after radical surgery was not effective for this patient who had a primary cervical melanoma that metastasized to bone and lung tissue. We do not know why pembrolizumab was ineffective for this patient, but there are several possible explanations; further research is needed.

References

Feb 10, 1999·São Paulo Medical Journal = Revista Paulista De Medicina·J C TeixeiraL A Andrade
Mar 14, 2007·Journal of the American Academy of Dermatology·Ronald J PatrickJane L Messina
Apr 28, 2011·Cancer·Jules GadiotChristian Blank
May 23, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maria ColombinoGiuseppe Palmieri
Apr 22, 2015·The New England Journal of Medicine·Caroline RobertUNKNOWN KEYNOTE-006 investigators
Apr 20, 2016·JAMA : the Journal of the American Medical Association·Antoni RibasCaroline Robert
Jul 2, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Claus GarbeUNKNOWN European Organisation for Research and Treatment of Cancer (EORTC)
Jul 28, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M C T van ZeijlM W J M Wouters

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Citations

Dec 31, 2020·International Journal of Molecular Sciences·Fulvio BorellaLeonardo Micheletti
Feb 26, 2021·Case Reports in Oncological Medicine·Michail DiakosavvasEmmanuel N Kontomanolis
Jun 3, 2021·Journal of Personalized Medicine·Mayuka AnkoDaisuke Aoki
Jul 6, 2021·International Cancer Conference Journal·Reiko SuzukiNao Suzuki

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Methods Mentioned

BETA
surgical resection
hysterectomy
biopsy

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