Primary malignant tumors of the heart: four cardiovascular hormones decrease the number and DNA synthesis of human angiosarcoma cells

Cardiology
Brian A VeselyD L Vesely

Abstract

A family of six cardiovascular hormones--atrial natriuretic peptide, brain natriuretic peptide, C-natriuretic peptide, long acting natriuretic peptide, vessel dilator and kaliuretic peptide--was investigated for the ability to decrease the number of human angiosarcoma cells. Within 24 h, vessel dilator, long acting natriuretic peptide, kaliuretic peptide, atrial natriuretic peptide and their intracellular mediator cyclic GMP decreased the number of angiosarcoma cells by 61, 30, 29, 36 and 32%, respectively, and DNA synthesis by 68-85%. Brain natriuretic peptide and C-natriuretic peptide had no effect(s). The natriuretic peptide receptor C was present. Four cardiovascular hormones decrease the number of angiosarcoma cells within 24 h via inhibition of DNA synthesis mediated in part by cyclic GMP.

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Citations

Mar 28, 2013·Endocrine-related Cancer·David L Vesely
Nov 16, 2007·The American Journal of the Medical Sciences·Brian A VeselyDavid L Vesely
Oct 13, 2006·European Journal of Clinical Investigation·B A VeselyD L Vesely
Aug 28, 2009·American Journal of Physiology. Cell Physiology·Abdel A Alli, William R Gower
Jul 9, 2021·Biomedical Journal·Mengjiao XuGeng Yang

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