Abstract
Primary mediastinal germ tumours (PMGCT) constitute, a mere 3-4% of all germ cell tumours (GCT). Although they account for approximately 16% of mediastinal tumours in adults and 19-25% in children as per western literature, there is hardly any large series on PMGCT reported from the Indian subcontinent. We have retrospectively analysed clinicopathological features of 98 cases of PMGCT diagnosed over 10 years (2010-2019) from a tertiary-care oncology centre. The study group (n = 98) comprised predominantly of males (n = 92) (M:F ratio-15:1), with an age range between 3 months to 57 years (median: 25 years). The tumours were predominantly located in the anterior mediastinum (n = 96). Broadly, Non-seminomatous germ cell tumours (NSGCT) were more common (n = 73, 74%) compared to pure seminoma (n = 25, 26%). Mixed NSGCT was the most common histological subtype (n = 30) followed by pure mature teratoma (n = 18), pure Yolk sac tumour (n = 13), mixed seminoma and NSGCT (n = 5), pure immature teratoma (n = 3) and GCT; NOS (n = 4). Interestingly, all female patients had exclusive teratomas. Nine cases revealed secondary somatic malignancy (5 carcinomas and 4 sarcomas). The majority of patients received neoadjuvant chemotherapy (n = 71). ...Continue Reading
References
Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·C CaballeroJ Prat
Sep 15, 1990·Cancer·J L Gonzalez-VelaB J Kennedy
May 17, 1990·The New England Journal of Medicine·C R NicholsG Tricot
Sep 1, 1987·The Annals of Thoracic Surgery·R D DavisD C Sabiston
Apr 1, 1994·Cancer·P E GossF A Shepherd
Feb 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Sep 23, 1997·The American Journal of Surgical Pathology·C A Moran, S Suster
Dec 11, 2002·Chest Surgery Clinics of North America·Victor E Reuter
Jan 9, 2003·Cancer·Shin-ichi TakedaHikaru Matsuda
May 20, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Carsten BokemeyerLawrence Einhorn
May 2, 2007·Advances in Anatomic Pathology·Jesse K McKenneyRobert V Rouse
Aug 28, 2007·The American Journal of Surgical Pathology·Hugo Domínguez MalagónSaul Suster
Jan 29, 2008·The Annals of Thoracic Surgery·Kenneth A KeslerJohn W Brown
Aug 17, 2010·Interactive Cardiovascular and Thoracic Surgery·Caroline RiveraMarc Riquet
May 26, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Inderpal S SarkariaValerie W Rusch
Aug 15, 2015·Thoracic Cancer·Jianyang WangLuhua Wang
May 29, 2016·Cancer Epidemiology·Marina T van LeeuwenClaire M Vajdic
May 12, 2019·Seminars in Oncology·Giovanni RostiPaolo Pedrazzoli
Jan 21, 2020·South Asian Journal of Cancer·Subhasis MishraDillip Kumar Parida
Mar 30, 2021·Ecancermedicalscience·Anjana JoelAshish Singh