PMID: 8597843Jul 1, 1995Paper

Primary mediastinal large cell lymphoma in children: a report from the Childrens Cancer Group

Pediatric Pathology & Laboratory Medicine : Journal of the Society for Pediatric Pathology, Affiliated with the International Paediatric Pathology Association
T PiiraC R Kjeldsberg

Abstract

Malignant lymphomas arising in the mediastinum account for approximately 60% of all mediastinal tumors in children; two-thirds are non-Hodgkin's lymphomas and one-third represent Hodgkin's disease. In contrast to adults, in children mediastinal non-Hodgkin's lymphomas are usually synonymous with lymphoblastic lymphoma, and nonlymphoblastic lymphomas are rare. We describe nine children with primary mediastinal large cell lymphoma who were treated with the Children's Cancer Group protocol CCG-503, a randomized phase III protocol for disseminated nonlymphoblastic lymphoma. Histologic subclassification revealed three immunoblastic lymphomas, three multilobated large cell lymphomas, one with clear cell features, and two large noncleaved cell lymphomas. Sclerosis, of variable degrees, was seen in all tumors. Immunophenotyping revealed all tumors to be of B cell lineage. Thymic epithelial cells could be demonstrated, utilizing antibody to keratin, in two of nine patients, suggesting that some of the tumors are of thymic origin. None of the patients had central nervous system or bone marrow involvement. It appears that primary mediastinal nonlymphoblastic lymphomas in children, although much less common, are similar to those seen in ad...Continue Reading

References

Jan 1, 1979·Archives of Surgery·J S Elder, R J Touloukian
Aug 1, 1977·Archives of Surgery·R J Bower, W B Kiesewetter
Jul 19, 1977·Journal of Mathematical Biology·M E Fisher, B S Goh
May 15, 1992·Cancer·T Lavabre-BertrandM Navarro
Sep 1, 1989·The American Journal of Surgical Pathology·L LamarreN L Harris
Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·A ScarpaL Fiore-Donati
Feb 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N J BuninS B Murphy
Jun 1, 1985·American Journal of Clinical Pathology·S A YousemR A Warnke
Mar 1, 1986·The American Journal of Surgical Pathology·T PerroneJ Rosai
Jul 1, 1983·Human Pathology·C R KjeldsbergC W Berard
Aug 4, 1983·The New England Journal of Medicine
Apr 1, 1980·The American Journal of Medicine·A K LichtensteinR J Lukes
Dec 1, 1982·Cancer·L J LevittS Poppema
Oct 1, 1982·Journal of Pediatric Surgery·R M KingM T Han
Jun 1, 1993·Journal of Clinical Pathology·T F CarrA M Kelsey

❮ Previous
Next ❯

Citations

Dec 3, 1999·British Journal of Haematology·C R Pinkerton
Dec 25, 2004·Seminars in Thoracic and Cardiovascular Surgery·James Jaggers, Keki Balsara
May 2, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K SeidemannUNKNOWN NHL Berlin-Frankfurt-Münster Group
Jul 13, 2000·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·S L Perkins
Nov 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M A LonesM S Cairo

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.