Primary meningococcal conjunctivitis: report of 21 patients and review

Reviews of Infectious Diseases
N BarquetR Elcuaz


Neisseria meningitidis is an uncommon cause of acute bacterial conjunctivitis. Twenty-one cases of primary meningococcal conjunctivitis (PMC) are reported herein and 63 cases published in the literature since 1899 are reviewed. In the 84 cases of PMC available for analysis, the male-to-female ratio was 1.76:1; nine of the patients were neonates, 55 were children, and 20 were adults. Conjunctivitis was unilateral in 66.3% of the patients. Gram stain of conjunctival exudate disclosed gram-negative diplococci in all cases in which it was done. Culture of the conjunctival exudate yielded N. meningitidis in all cases, and 44% of the isolated meningococci belonged to serogroup B. Ocular complications, which occurred in 15.5% of the patients, most frequently were corneal ulcers. Systemic meningococcal disease developed in 17.8% of the patients; the overall mortality was 13.3% for patients with PMC complicated by systemic disease. Development of systemic disease was significantly more frequent in patients receiving only topical therapy than in those treated with systemic therapy (31.71% vs. 2.38%; P = .001). Gram-negative diplococci observed in conjunctival exudate are an indication for systemic antibiotic therapy because of the risk o...Continue Reading


May 1, 1994·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J Anderson, I Lind
Jan 1, 1994·Current Problems in Pediatrics·A Weiss
Nov 23, 1996·Lancet·G HoldsworthE B Kaczmarski
Jan 13, 1996·Lancet·P DomingoF A Moraga-Llop
May 1, 1997·Australian and New Zealand Journal of Ophthalmology·F Irani, T Ruddell
Jan 11, 2000·Clinical Microbiology Reviews·M van DeurenJ W van der Meer
Aug 9, 2003·Journal of Clinical Microbiology·Gian-Luigi CartolanoJan Hayon
Sep 1, 1994·The British Journal of Ophthalmology·C AranzastiL Gaztelurrutia
Sep 15, 2000·The Western Journal of Medicine·C W Chung, E J Cohen
Feb 3, 2011·JRSM Short Reports·G P WilliamsS Rauz
Jul 9, 2013·Critical Care Clinics·Paul A CampsallDaniel J Niven
Oct 1, 2005·Medical Journal, Armed Forces India·Sharat JohriA C Anand
Oct 26, 1999·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·S S Lehman
Oct 18, 2008·Journal of Medical Microbiology·A L de Souza, Antonio Carlos Seguro
May 25, 2012·Vaccine·David Pace, Andrew J Pollard
May 4, 2017·Clinical & Experimental Ophthalmology·Wesley Wh Teoh, Katherine J Walker
Apr 22, 2008·Clinical Pediatrics·Ruchi GuptaMorven S Edwards
Jul 5, 2008·Clinical Pediatrics·A L de Souza, Antonio Carlos Seguro
May 3, 2001·The New England Journal of Medicine·N E RosensteinJ M Hughes
Nov 1, 1993·Acta Paediatrica·L H HagelskjaerL P Blichfeld
Sep 1, 1994·The British Journal of Ophthalmology·A Callear, G Kirkby
Jun 11, 2009·Cornea·Joseph A Elias, Rahul T Pandit
Sep 28, 2004·Cornea·Christopher M AndreoliLynnette M Watkins
Sep 9, 1999·Journal of Clinical Gastroenterology·J CollazosJ Mayo
Mar 5, 2004·ANZ Journal of Surgery·Steven J Kelly, Robert W Robertson
Jun 23, 2020·Emerging Infectious Diseases·Eva L SudburyKeshan Satharasinghe
Mar 10, 2001·Scandinavian Journal of Infectious Diseases·M C PorrasL C Martín Martín
Sep 2, 2004·Paediatric Drugs·Jens U Rüggeberg, Andrew J Pollard
Dec 22, 2019·Pathogens·Maria Victoria Humbert, Myron Christodoulides
Aug 12, 1998·Revista de saúde pública·D E BarrosoC A Solari
Oct 1, 2011·Asian Pacific Journal of Tropical Biomedicine·Jakiyah DaudWan Hazabbah Wan Hitam
Nov 26, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Dimitrios FilippakisAgeliki Karatza
Oct 13, 2018·The Medical Journal of Australia·James SterreyTim Rm Henderson

Related Concepts

Bacterial Conjunctivitis
Meningococcal Infections
Retrospective Studies

Related Feeds

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Related Papers

Christopher M AndreoliLynnette M Watkins
European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
J Anderson, I Lind
© 2021 Meta ULC. All rights reserved