Primary mixed glioneuronal tumor of the central nervous system in a patient with noonan syndrome: a case report and review of the literature

Journal of Pediatric Hematology/oncology
Courtney B ShermanGirish Dhall

Abstract

Noonan syndrome is an autosomal dominant condition with variable phenotypic expression. Although an association between Noonan syndrome and various neoplasms has been identified, a relationship with primary glial or neuronal tumors of the central nervous system (CNS) has not yet been established. We describe the case of a 6-year-old male patient with Noonan syndrome and leptomeningeally disseminated low-grade mixed glioneuronal tumor. After a literature review, this case emerges as the third patient to present with Noonan syndrome and primary CNS glial tumor and the first with mixed glioneuronal tumor, indicating the possible association between these individual entities.

References

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Mar 7, 2006·Genes, Chromosomes & Cancer·Yuyan ChenYasuhide Hayashi
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Feb 8, 2007·Archives of Pathology & Laboratory Medicine·Mark A Edgar, Marc K Rosenblum

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Citations

Mar 17, 2011·European Journal of Human Genetics : EJHG·Marjolijn C J JongmansNicoline Hoogerbrugge
Feb 17, 2015·Clinical Genetics·P SmpokouM L Summar
Jan 15, 2015·Pediatric Blood & Cancer·Sushmita NairCharles A Williams
Dec 22, 2016·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Matthias W WagnerThierry A G M Huisman
Mar 23, 2017·American Journal of Medical Genetics. Part a·Aurore SiegfriedMarie-Bernadette Delisle
Aug 19, 2020·Diagnostics·Mariachiara LodiAngela Mastronuzzi
Sep 18, 2015·American Journal of Medical Genetics. Part a·Geoffrey D McWilliamsCarol Clericuzio

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