Primary neuroendocrine carcinoma coexisting with hemangioma in the liver: report of a case.

Surgery Today
Tomohiko AkahoshiYoichi Muto

Abstract

Primary hepatic neuroendocrine carcinoma is an extremely rare liver tumor. We herein report a case of primary hepatic neuroendocrine carcinoma coexisting with a hemangioma in a 66-year-old man. Ultrasonography, computed tomography, and magnetic resonance imaging showed a tumor (1.5 cm in diameter) coexisting with a hemangioma in the lateral segment of the liver. Liver biopsy showed malignant cells, and several examinations revealed no alternative primary source. We performed a lateral segmentectomy. Microscopically, the tumor cells had round to oval nuclei and eosinophilic cytoplasm, proliferated in thick trabeculae or solid nests, and formed a focal rosette pattern. Mitotic cells were frequently observed. Immunohistochemically, the tumor cells were positive for the endocrine markers chromogranin A, neuron-specific enolase, and neural cell adhesion molecule, but negative for alpha-fetoprotein and hepatocyte-specific antigen. The patient is still alive after 3 months, without recurrence.

Citations

Mar 15, 2012·Journal of Gastroenterology and Hepatology·Chan Hyuk ParkJeong Youp Park
Jan 29, 2016·Journal of Korean Neurosurgical Society·Guk Jin LeeIl Young Park
Jul 14, 2018·Journal of Gastrointestinal Cancer·Yakup BozkayaE Yılmaz
Sep 13, 2017·Surgical Case Reports·Richi NakatakeMasanori Kon
Mar 7, 2018·BMC Clinical Pathology·Zi-Ming ZhaoJeffrey P Townsend
Nov 3, 2021·Surgical Case Reports·Yusuke SekiMasahiro Ishimaru

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