Primary neuroendocrine carcinoma of the vagina with Merkel cell carcinoma phenotype

The American Journal of Surgical Pathology
Neil M ColemanJon A Reed

Abstract

We describe a case of primary neuroendocrine carcinoma arising from the anterior vaginal wall of a 67-year-old woman. Primary neuroendocrine carcinoma of the vagina is a rare entity with only 25 previously reported cases in the literature. In previous reports, these tumors have not been distinguished from primary neuroendocrine carcinoma of the skin (Merkel cell carcinoma). The tumor was composed of cells that showed neuroendocrine-type nuclear features with hyperchromasia, nuclear molding, occasional small nucleoli, and a chromatin pattern that was finely granular. The tumor cells were positive for cytokeratin 20 (CK20), neuron specific enolase, pancytokeratin, epithelial membrane antigen, and chromogranin A expression. Ki-67, a marker of proliferation, was also positive in>90% of cells. The tumor cells showed intense expression of Bcl-2 oncoprotein and mild to moderate expression of c-KIT. Synaptophysin, neurofilament, CD45, CD56, CD10, S-100, HMB-45, cytokeratin 7, and thyroid transcription factor 1 were negative. This pattern of staining is consistent with a Merkel cell carcinoma. This is the first report of a primary neuroendocrine carcinoma of the vagina with a Merkel cell phenotype. Previous studies have not distinguishe...Continue Reading

Citations

Nov 9, 2012·Histopathology·W Glenn McCluggage
Jul 19, 2008·Histopathology·W G McCluggage
Oct 24, 2007·American Journal of Clinical Pathology·Francisco Alijo SerranoEmilio Alvarez-Fernández
Jan 15, 2014·Rare Tumors·Ryosuke TamuraHideki Mizunuma
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Jun 26, 2013·Wiener medizinische Wochenschrift·José Carlos CardosoUwe Wollina
Apr 26, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Nelson G Ordóñez
Apr 15, 2014·Endocrine Pathology·Sofia AsioliVincenzo Eusebi
Jul 24, 2012·Current Opinion in Oncology·Joshua G CohenDaniel S Kapp
Oct 16, 2014·Head and Neck Pathology·Davide LombardiPiero Nicolai
May 3, 2021·Critical Reviews in Oncology/hematology·Giuseppe CarusoInnocenza Palaia

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