Primary neuroendocrine tumors of the breast: two case reports and review of the literature

Journal of Medical Case Reports
Loubna HejjaneNawef Mellas

Abstract

Neuroendocrine carcinomas mainly affect the bronchopulmonary and the gastrointestinal systems. Breast localizations are very rare. They represent less than 0.1% of all breast cancers. A definitive diagnosis relies on histological and immunohistochemical examinations. Case 1 We report a case of primary neuroendocrine carcinoma of the breast in a 71-year-old Arabic woman who presented with a 3 cm palpable and mobile tumor of the right breast. Clinical and radiological assessment excluded any other primary tumor. Radical mastectomy and axillary lymph node resection were performed. A histopathological examination disclosed the diagnosis of primary breast neuroendocrine tumors, with negative surgical margins and lymph nodes (18 N-/18 N). The tumor cells were positive for neuroendocrine markers, a weak Ki-67 proliferation index and negative Her2/neu. Our patient received adjuvant hormonal treatment with anti-aromatase for 21 months. She is on regular follow-up, and she remains free of disease to date. Case 2 A 48-year-old Arabic woman consulted for a right breast nodule. She underwent lumpectomy with right axillary lymphadenectomy. The diagnosis was breast neuroendocrine tumor. Systemic treatment was proposed, but she was lost to fol...Continue Reading

References

Aug 16, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·A SapinoG Bussolati
May 9, 2007·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Yasuhisa FujimotoSuzuko Moritani
Sep 17, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Abid IrshadBeata Panzegrau
Jan 13, 2009·Indian Journal of Pathology & Microbiology·Kafil AkhtarM Jaseem Hassan
May 29, 2009·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Takuya MoriyaMika Watanabe
Aug 22, 2009·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·Z BourhalebA Benider
Oct 13, 2009·Histopathology·Gary M TseTakuya Moriya
Oct 19, 2010·Annales de chirurgie plastique et esthétique·B PotierP Rousseau
Jun 30, 2011·Journal of Cytology·Sunita SinghRajeev Sen

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Citations

Nov 4, 2020·Intractable & Rare Diseases Research·Nikolaos S Salemis
Feb 16, 2021·Frontiers in Endocrinology·Marco GalloAnnamaria Anita Livia Colao

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Methods Mentioned

BETA
biopsy
microbiopsy
dissection

Software Mentioned

Octreoscan
Breast Imaging Reporting and Data System ( BIRADS )

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