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Primary Neurons and Differentiated NSC-34 Cells Are More Susceptible to Arginine-Rich ALS Dipeptide Repeat Protein-Associated Toxicity than Non-Differentiated NSC-34 and CHO Cells

International Journal of Molecular Sciences

Dec 15, 2019

Anna L GillFernando G Vieira

Abstract

A repeat expansion mutation in the C9orf72 gene is the most common known genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). In this study, using multiple cell-based assay systems, we reveal both increased dipeptide repeat protein (DRP) toxicity in pr...read more

Mentioned in this Paper

Study
Flow Cytometry
RERE protein, human
Neurons
Poly-L-alanine
capsular polysaccharide, Streptococcus suis type 2
Cellular Assay
Poly(L-proline)
Motor Neurons
Amyotrophic Lateral Sclerosis
6
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Primary Neurons and Differentiated NSC-34 Cells Are More Susceptible to Arginine-Rich ALS Dipeptide Repeat Protein-Associated Toxicity than Non-Differentiated NSC-34 and CHO Cells

International Journal of Molecular Sciences

Dec 15, 2019

Anna L GillFernando G Vieira

PMID: 31835664

DOI: 10.3390/ijms20246238

Abstract

A repeat expansion mutation in the C9orf72 gene is the most common known genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). In this study, using multiple cell-based assay systems, we reveal both increased dipeptide repeat protein (DRP) toxicity in pr...read more

Mentioned in this Paper

Study
Flow Cytometry
RERE protein, human
Neurons
Poly-L-alanine
capsular polysaccharide, Streptococcus suis type 2
Cellular Assay
Poly(L-proline)
Motor Neurons
Amyotrophic Lateral Sclerosis
6

Similar Papers Found In These Feeds

ALS: Therapies

Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS therapies here.

Neuronal Cell Types

There are diverse ranges of neurons, which are defined by their structural, functional, connectional and molecular properties. For example, some type of neurons includes sensory, sympathetic, and motor neurons. Discover the latest research on neuronal cell types here.

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Paper Details
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