Primary omental gamma/delta T-cell lymphoma involving the central nervous system

Leukemia & Lymphoma
Y HaradaT Hayashi

Abstract

Gamma/delta T-cell lymphoma (GDTL) is an uncommon lymphoma that was initially reported to involve only the liver and spleen. GDTL other than the hepatosplenic type is extremely rare. Frequent primary sites include skin and subcutaneous tissue, intestine, or nasal region. We report a case of GDTL of the omentum in a 54 year-old-man. The tumor cells are CD2-, CD3+, CD4-, CD5-, CD8+, CD56+, TIA-1+, granzyme B+/-. They expressed the identical phenotype of intestinal GDTL. The patient was treated with 2 courses of CHOP which comprised cyclophosphamide, doxorubicin, vincristine and prednisolone, and 3 courses of EPOCH which comprised etoposide, prednisolone, vincristine, cyclophosphamide and doxorubicin. However, he failed to obtain remission. During the fourth course of EPOCH, muscle weakness of the lower extremities developed and intracranial masses were observed by computed tomographic scan of the brain. Dissemination of lymphoma to the central nervous system was considered and it may be attributable to the expression of CD56 in this case. High dose methotrexate (HD-MTX) chemotherapy successfully eliminated the omental tumor and reduced the size of the intracranial masses, thus HD-MTX appears to be an effective treatment against G...Continue Reading

Citations

Apr 5, 2011·Antioxidants & Redox Signaling·Laura A A Gilliam, Daret K St Clair
Apr 4, 2014·The Lancet Oncology·Andrés J M Ferreri
Jun 15, 2007·La Revue de médecine interne·M-O ChandesrisJ-M Durand
Mar 29, 2019·Current Oncology Reports·Ashley E Aaroe, Kathryn S Nevel
Dec 16, 2020·Pharmaceuticals·Fatima Bianca A DessoukiDinender K Singla

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