Primary orbital mesenchymal chondrosarcoma: a case report and literature review

International Ophthalmology
Alexandre Nakao OdashiroMiguel N Burnier

Abstract

Mesenchymal chondrosarcoma (MC) is a subtype of chondrosarcoma, with an incidence varying from 1 to 8% of all chondrosarcomas. It is an aggressive neoplasm with a high tendency for late recurrence and occasional delayed distant metastasis. Orbital MC is very rare, and only approximately 30 cases have been described in the literature. We describe here one case of primary orbital MC. A 14-year-old boy without a past medical history presented with a 1-month history of progressive proptosis on the right eye. Computed tomography (CT) scans of the orbit revealed a right intraconic lesion, with areas of calcification. The lesion was excised. Histopathological analysis revealed that the tumor had a biphasic pattern, showing a combination of small cell malignancy and well-differentiated cartilage. Immunohistochemistry examination revealed a diffuse membrane expression of CD99 on the small cell malignancy; S-100 was positive only within the cartilage component. The patient received chemotherapy, and no metastatic disease was found at the 2-month follow-up. Although rare, MC should be considered in the differential diagnosis of a well-circumscribed orbital lesion in young adults, especially when CT scans reveal areas of calcification with...Continue Reading

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Citations

Jan 3, 2012·Archives of Pathology & Laboratory Medicine·Rachel J ShakkedHoward D Dorfman
Oct 23, 2010·International Ophthalmology·Alexandre N OdashiroMiguel N Burnier
Nov 7, 2012·International Ophthalmology·Hayyam KiratliMetin Onerci
Dec 20, 2011·Clinical Radiology·B T YangZ C Wang
Jun 27, 2012·British Journal of Neurosurgery·Zhisheng KanChao You
Dec 17, 2014·BMC Surgery·Vitalie GhermanIoan Coman
Aug 28, 2016·World Neurosurgery·Nishanth SadashivaBhagavatula Indira Devi
Jul 6, 2018·The British Journal of Radiology·Mitsuteru TsuchiyaHarumi Sakahara
Jun 5, 2018·The Journal of Craniofacial Surgery·Abbas BagheriMozhgan Rezaei Kanavi
Jul 21, 2009·Ophthalmic Plastic and Reconstructive Surgery·Kaan GündüzDuygu Kankaya
Oct 26, 2012·Neurologia Medico-chirurgica·Shunya HanakitaNobuhito Saito
May 15, 2018·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Hind M AlkatanAzza M Y Maktabi
Jan 9, 2015·The Journal of Craniofacial Surgery·Vasily A CherekaevTatiana V Tsukanova

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