Primary Pancreatic Lymphoma Masquerading as Carcinoma

Case Reports in Oncological Medicine
Nasser A N Alzerwi

Abstract

Adenocarcinoma is the most common primary pancreatic neoplasm type, followed by secondary pancreatic lymphoma and primary pancreatic lymphoma (PPL). PPL is associated with peripancreatic lymphadenopathy and usually presents as a homogenous mass with extrapancreatic invasion into surrounding structures. However, localized involvement of the distal pancreas is uncommon, and diffuse involvement of the pancreas is even rarer. Herein, we present the case of a 53-year-old woman with PPL of the uncinate process with biliary obstruction mimicking pancreatic adenocarcinoma, successfully diagnosed nonoperatively. Abdominal computed tomography showed an ill-defined uncinate process mass, hypodense with mild enhancement (3.9 × 3.4 × 3.5 cm), infiltrating the second and third parts of the duodenum. Biopsy revealed NHL with no evidence of adenocarcinoma. PPL was diagnosed. She received chemotherapy with a CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) protocol with rituximab, which she tolerated with no clinical or radiological evidence of recurrence at 1-year follow-up.

References

Oct 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P MauchG Canellos
Apr 8, 1993·The New England Journal of Medicine·J O Armitage
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E ZuccaUNKNOWN International Extranodal Lymphoma Study Group
Oct 20, 2005·Clinical Lymphoma & Myeloma·Karen H ShaharBin S Teh
Jul 27, 2006·Pancreas·Narendra BattulaNigel Heaton
Jun 27, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E Zucca
Jun 5, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yosho FukitaYoshiki Katakura
Jun 21, 2013·Hematological Oncology·John F Seymour

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Citations

May 14, 2021·Journal of Blood Medicine·Davide FacchinelliCristina Tecchio

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Methods Mentioned

BETA
X-ray
biopsy
flow cytometry
open

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