Primary pancreatic lymphomas: a cytopathologic analysis of a rare malignancy

Cancer
Hassan NayerSyed Z Ali

Abstract

Primary pancreatic lymphomas (PPL) are extremely rare. Clinically, PPL usually present with symptoms of carcinoma of the pancreatic head. An accurate cytopathologic diagnosis by fine-needle aspiration (FNA) is imperative because the primary treatment is nonsurgical, based on a combination of chemotherapy and radiation therapy. Eight cases of PPL were identified from the pathology files of The Johns Hopkins Hospital over a 14-year period (1989-2003). All cases were diagnosed on FNA performed under radiologic guidance. Needle rinses were used to perform flow cytometric (FC) analysis. No tissue studies were performed after the FNA diagnosis was made. A strong male predominance (male-to-female ratio of 7:1) was noted. The patients ranged in age from 35-75 years (mean age, 55 years). The tumors varied in size from 2-14 cm, as evaluated on the radiologic scans (mean dimension of 8.0 cm). Abdominal pain was the most common presenting symptom (six patients) followed by jaundice, acute pancreatitis, small bowel obstruction, and diarrhea. The cytomorphologic features included hypercellularity with discohesive cells with round nuclei, often prominent nucleoli, mitoses, and karyorrhexis. By FC analysis, all eight cases demonstrated a monoc...Continue Reading

References

Jan 1, 1989·Annals of Surgery·T H WebbJ L Cameron
Sep 1, 1994·Pancreas·K E BehrnsJ G Strickler
Sep 1, 1996·Journal of Clinical Gastroenterology·A EzzatI Taha
May 12, 1998·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·M HammC Fiedler
Mar 7, 2001·Surgery·S Islam, M P Callery
May 2, 2002·Surgical Endoscopy·L BoniR Dionigi

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Citations

Mar 29, 2006·Annals of Hematology·I AlldingerW T Knoefel
Jul 27, 2006·Pancreas·Narendra BattulaNigel Heaton
Dec 3, 2011·American Journal of Clinical Oncology·Mark V MishraTithi Biswas
Aug 3, 2012·Case Reports in Gastroenterology·Mehdi GhobakhlouMohammad Reza Zali
May 21, 2008·Journal of Medical Case Reports·Theodore LiakakosAnastasios Macheras
Jan 1, 2009·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Altaf Gauhar HajiM Dinesh
Jul 4, 2013·Journal of Gastrointestinal Cancer·Jignesh G ParikhHuijun Dong
Jul 13, 2012·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Dushyant V SahaniMichael A Blake
Jul 20, 2011·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Gavin LowEdward Leen
Apr 12, 2006·European Journal of Gastroenterology & Hepatology·Yu Jen WangTsung His Wang
Dec 1, 2008·Clinical Journal of Gastroenterology·Taichi NakamuraRyoichi Takayanagi
Mar 21, 2013·Insights Into Imaging·Yasunari FujinagaMasumi Kadoya
Jan 19, 2016·International Journal of Surgery·Michele ScialpiSalvatore Cappabianca
Feb 18, 2012·American Journal of Clinical Pathology·Jonathan RockWendy L Frankel
Nov 20, 2009·Gastroenterología y hepatología·Luis Vida PérezEnrique Fraga Rivas
Mar 3, 2006·Diagnostic Cytopathology·Ricardo H BardalesMichael W Stanley
May 10, 2008·American Journal of Surgery·Melinda M MortensonJason B Fleming
Apr 2, 2010·Journal of Korean Medical Science·Won Jae YoonYong-Tae Kim
Aug 15, 2014·Abdominal Imaging·Kumar SandrasegaranChristine O Menias
Nov 28, 2019·Diagnostic Cytopathology·Omid SavariSalman Ayub
Jun 21, 2019·ANZ Journal of Surgery·Alexander Mimery, Stefaan De Clercq
May 24, 2006·World Journal of Gastroenterology : WJG·Abby-L MulkeenCharles Cha
Jan 30, 2020·Minerva gastroenterologica e dietologica·Julio Iglesias-GarciaJ Enrique Dominguez-Muñoz
Mar 12, 2020·Case Reports in Oncological Medicine·Nasser A N Alzerwi
May 18, 2020·Journal of Gastrointestinal Cancer·Jonathan KopelSriman Swarup
Aug 29, 2006·World Journal of Gastroenterology : WJG·Hai LinZhao-Shen Li
Feb 18, 2020·Proceedings·Madhuri BadrinathDavid Heisig
May 14, 2021·Journal of Blood Medicine·Davide FacchinelliCristina Tecchio
Jul 18, 2021·Seminars in Nuclear Medicine·Patrick PilkingtonKen Herrmann

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