Primary peritoneal anaplastic giant cell carcinoma: case report of an unusual and highly malignant müllerian neoplasm.

Archives of Pathology & Laboratory Medicine
Xian LuW Dwayne Lawrence

Abstract

Virtually all primary peritoneal carcinomas (PPCs) are of serous papillary type. We report an unusual histologic type of PPC composed of anaplastic giant cells, which exhibited an aggressive clinical course. A 72-year-old woman presented with lower abdominal pain. Computed tomography showed a diffuse omental thickening. The patient underwent an exploratory laparotomy with omentectomy, total hysterectomy, bilateral salpingo-oophorectomy, and appendectomy. Pathologic examination revealed extensive omental replacement by tumor but only superficial surface cortical involvement of both ovaries, a disease distribution consistent with a typical müllerian-derived PPC. However, this neoplasm was composed of diffuse anaplastic tumor giant cells, rather than serous carcinoma, which is the usual histologic type encountered in PPC. The patient died within 1 month after surgery. We report this unusual histologic variant of PPC to raise awareness that anaplastic giant cell carcinoma may arise in the pelvic peritoneum as a primary tumor.

References

Feb 1, 1977·American Journal of Obstetrics and Gynecology·M KannersteinD P Hill
Mar 1, 1990·The American Journal of Surgical Pathology·D A Bell, R E Scully
Mar 1, 1972·Obstetrical & Gynecological Survey·S C Lauchlan
Jan 1, 1982·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·S GooneratneA Talerman
Jan 19, 2000·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·R H Young
Aug 16, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Charlotte Winther MadsenLise Grupe Larsen

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