Primary photophysical properties of moxifloxacin--a fluoroquinolone antibiotic

Photochemistry and Photobiology
Fernando LorenzoNorman S Allen

Abstract

The photophysical properties of the fluoroquinolone antibiotic moxifloxacin (MOX) were investigated in aqueous media. MOX in water, at pH 7.4, shows two intense absorption bands at 287 and 338 nm (epsilon = 44,000 and 17,000 dm(3) mol(-1) cm(-1), respectively). The absorption and emission properties of MOX are pH-dependent, pK(a) values for the protonation equilibria of both the ground (6.1 and 9.6) and excited singlet states (6.8 and 9.1) of MOX were determined spectroscopically. MOX fluoresces weakly, the quantum yield for fluorescence emission being maximum (0.07) at pH 8. Phosphorescence from the excited triplet state in frozen ethanol solution has a quantum yield of 0.046. Laser flash photolysis and pulse radiolysis studies have been carried out to characterize the transient species of MOX in aqueous solution. On laser excitation, MOX undergoes monophotonic photoionization with a quantum yield of 0.14. This leads to the formation of a long-lived cation radical whose absorption is maximum at 470 nm (epsilon(470) = 3400 dm(3) mol(-1) cm(-1)). The photoionization process releases hydrated electron which rapidly reacts (k = 2.8 x 10(10) dm(3) mol(-1) s(-1)) with ground state MOX, yielding a long-lived anion radical with maximu...Continue Reading

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Citations

Mar 27, 2009·Photochemistry and Photobiology·Virginie Lhiaubet-ValletMiguel Angel Miranda
Jun 11, 2009·Photochemistry and Photobiology·Fernando LorenzoNorman S Allen
Jul 21, 2011·Photochemistry and Photobiology·Guido de GuidiAlfio Catalfo
Feb 11, 2012·Photochemistry and Photobiology·Yancheng LiuWenfeng Wang
Dec 12, 2012·Journal of Photochemistry and Photobiology. B, Biology·Yancheng LiuWenfeng Wang
Sep 17, 2014·The Science of the Total Environment·Xander Van DoorslaerKristof Demeestere
Dec 22, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Urszula HubickaDaniel Pawłowski
Aug 11, 2011·Organic & Biomolecular Chemistry·Ali El-Agamey, Shunichi Fukuzumi
Nov 24, 2017·Journal of Colloid and Interface Science·Fanny E K Okaikue-WoodiLudmilla Aristilde

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