Primary pleuropulmonary synovial sarcoma: reappraisal of a recently described anatomic subset

Cancer
Lydia R EssaryC D M Fletcher

Abstract

Primary pleuropulmonary synovial sarcoma (SS) is a rare neoplasm and a recently recognized anatomic subset. Its clinicopathologic attributes are not yet well defined. In this study, the clinical and histopathologic features of 12 SS arising in the lung and/or pleura were analyzed. The neoplasms occurred in 7 men and 5 women, 20-72 years old (median, 31 years), were well circumscribed with a mean size of 7.2 cm, and involved either lung (9 cases), pleura (2 cases), or both (1 case). All the tumors were of monophasic type. Nine showed a classic spindle cell pattern, and three showed predominantly poorly differentiated features. All but one case showed at least focal positivity for epithelial membrane antigen (EMA), a finding characteristic of this tumor. The lack of EMA staining in one case, proven by electron microscopy to be SS, was attributed to the scarcity of material available for immunohistochemical stains. The diagnosis was proven cytogenetically in three cases. Within 2 years, local recurrence developed in 8 patients (75%), 3 of whom developed metastasis (25%). Five patients died of their disease within 2.5 years, 4 of them from uncontrolled local disease. The authors conclude that pleuropulmonary SS, although rare, repr...Continue Reading

References

Mar 1, 1992·Journal of Clinical Pathology·N RatnatungaC D Fletcher
Nov 1, 1992·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·F R AmbleR L Foote
Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·M TsuneyoshiM Enjoji
Jun 1, 1989·The American Journal of Surgical Pathology·G B WitkinJ Rosai
Oct 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J R Mullen, G K Zagars
Jan 1, 1996·The American Journal of Surgical Pathology·E GaertnerW D Travis
May 1, 1996·Cancer Genetics and Cytogenetics·C A RobertsJ A Bridge
Apr 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S SingerJ M Corson
Apr 1, 1997·Histopathology·A G NicholsonC Fisher
Jan 31, 1998·Respiratory Medicine·D A JawaharP Magazeh
Jan 15, 1998·The New England Journal of Medicine·A KawaiM Ladanyi
Apr 16, 1998·Journal of Korean Medical Science·G S YoonO J Kim
May 19, 1998·Analytical Cellular Pathology : the Journal of the European Society for Analytical Cellular Pathology·J M LopesJ M Nesland
Jan 15, 1999·The American Journal of Surgical Pathology·M van de RijnC Fisher
May 13, 1999·Der Pathologe·C KuhnenV Haas
Jun 22, 1999·Cancer·P BerghL G Kindblom
Feb 5, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·S D BillingsE Tejada
May 1, 1965·Cancer·N L CADMANP J KELLY

❮ Previous
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Citations

May 14, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Masaaki YanoNobuyoshi Shimizu
May 22, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Esther OlivaRobert H Young
May 18, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nicolas WeinbreckFrançoise Galateau-Salle
Apr 28, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Paul H HartelTeri J Franks
Oct 17, 2008·Nature Reviews. Cancer·Steven J Harper, David O Bates
Apr 18, 2003·Journal of Thoracic Imaging·Alejandra Duran-MendicutiSara O Vargas
Jul 28, 2010·The American Journal of Surgical Pathology·Natalie M CummingsRobert C Rintoul
Apr 29, 2004·BMC Cancer·Jules J Berman
Jan 26, 2008·Journal of Medical Case Reports·Charalampos M MermigkisMichael Patentalakis
Feb 19, 2014·Clinical Nuclear Medicine·Giorgio TregliaSilvia Taralli
Jan 5, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Julia A Bridge
Jun 2, 2012·North American Journal of Medical Sciences·Pp RoyS Datta
Sep 15, 2005·Virchows Archiv : an International Journal of Pathology·Lars MorawietzIver Petersen
Jan 26, 2005·Virchows Archiv : an International Journal of Pathology·B Bode-LesniewskaR Caduff
May 17, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Aletta Ann FrazierJeffrey R Galvin
Sep 10, 2005·Expert Review of Molecular Diagnostics·Saul Suster, Cesar Moran
Feb 16, 2016·Internal Medicine·Hirokazu OginoYasuhiko Nishioka
Apr 21, 2012·Clinical Radiology·W-D ZhangC-X Li
Nov 24, 2004·Thoracic Surgery Clinics·Joseph M Corson
Oct 1, 2008·Clinical Lung Cancer·Michael MirzoyanHamed A Daw
Oct 31, 2013·Lung·Roger Fei Falkenstern-GeMartin Kohlhäufl
May 15, 2009·Journal of Cardiac Surgery·Narain MoorjaniGeoffrey Tsang
Jul 22, 2008·Head & Neck·Hiroto IshikiToru Motoi
Dec 9, 2008·Pediatric Pulmonology·John R PriestAdam Jaffé
Dec 5, 2008·Histopathology·Bruce Addis, Heather Roche
Jul 5, 2005·Cancer Genetics and Cytogenetics·Jun NishioJulia A Bridge
Apr 29, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Andrea FerrariModesto Carli
Mar 16, 2018·The American Journal of Surgical Pathology·Simone B S P TerraJennifer M Boland
Jun 13, 2018·Journal of Cancer Research and Therapeutics·Manoj Kumar PanigrahiPrasanta Raghab Mohapatra
Nov 18, 2006·The Kaohsiung Journal of Medical Sciences·Hsin-Hung ChenChee-Yin Chai
May 1, 2008·Ultrastructural Pathology·Julia A Bridge
Sep 11, 2014·The Korean Journal of Thoracic and Cardiovascular Surgery·Devrim CabukBahar Muezzinoglu
Oct 31, 2012·The American Journal of Surgical Pathology·Nagarjun RaoSaul Suster
Jan 1, 2015·SAGE Open Medical Case Reports·Hassan TahirVistasp Daruwalla

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