Primary Prevention Implantable Cardiac Defibrillators: A Townsville District Perspective

Frontiers in Cardiovascular Medicine
Nathan EngstromHayley L Letson

Abstract

Background: Despite major advances in treating patients with severe heart failure, deciding who should receive an implantable cardiac defibrillator (ICD) remains challenging. Objective: To study the risk factors and mortality in patients after receiving an ICD (January 2008-December 2015) in a regional hospital in Australia. Methods: Eighty-two primary prevention patients received an ICD for ischemic cardiomyopathy (ICM, n = 41) and non-ischemic cardiomyopathy (NICM, n = 40) with 4.8-yrs follow-up. One patient had mixed ICM/NICM indications. Ventricular arrhythmias were assessed using intracardiac electrograms. Statistical analysis compared the total population and ICM and NICM groups using Kaplan-Meier for survival, Cox regression for mortality predictors, and binary logistic regression for predictors of ventricular arrhythmias (p < 0.05). Results: Major risk factors were hypercholesterolemia (70.7%), hypertension (47.6%), and obesity (41.5%). Severe obstructive sleep apnea (OSA) was found exclusively in NICM patients (23.7%, p = 0.001). Mortality was 30.5% after 4.8-yrs. The majority of patients (n=67) had no sustained ventricular arrhythmias yet 28% received therapy (n = 23), 18.51% were appropriate (n = 15), and 13.9% inapp...Continue Reading

References

Jun 1, 1993·Journal of the American College of Cardiology·D BöckerG Breithardt
Mar 22, 2002·The New England Journal of Medicine·Arthur J MossUNKNOWN Multicenter Automatic Defibrillator Implantation Trial II Investigators
May 21, 2004·The New England Journal of Medicine·Alan KadishUNKNOWN Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation (DEFINITE) Investigators
Jan 22, 2005·The New England Journal of Medicine·Gust H BardyUNKNOWN Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators
Sep 18, 2007·Journal of the American College of Cardiology·Alfred E BuxtonUNKNOWN MUSTT Investigators
Jan 29, 2011·Journal of the American College of Cardiology·Johannes B van ReesMartin J Schalij
Apr 30, 2013·American Heart Journal·Pamela J BradshawMichael S T Hobbs
Jan 22, 2014·Journal of the American College of Cardiology·Jeffrey J GoldbergerAlan H Kadish
Mar 19, 2015·The American Journal of Cardiology·Laurent FauchierUNKNOWN DAI-PP Investigators
Jun 6, 2015·International Journal of Cardiology·Agustín Fernández-CisnalAlonso Pedrote
Nov 27, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Bruce L WilkoffShu Zhang
Nov 4, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Adolfo FontenlaIgnacio Fernández-Lozano
Aug 30, 2016·The New England Journal of Medicine·Lars KøberUNKNOWN DANISH Investigators
Mar 3, 2017·Journal of Cardiovascular Electrophysiology·Serge BovedaUNKNOWN DAI-PP Investigators
Apr 8, 2017·Journal of the American College of Cardiology·Pasquale SantangeliFrancis E Marchlinski
Aug 9, 2017·Cardiac Failure Review·Gianluigi Savarese, Lars H Lund
Oct 12, 2017·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Antonio D'OnofrioLuigi Padeletti
Jul 26, 2018·The Medical Journal of Australia·Bianca BlanchJodie Ingles
Mar 2, 2019·Journal of the American College of Cardiology·Javed ButlerMichael M Givertz
Jul 19, 2019·Clinical Cardiology·Thomas KleemannRalf Zahn
Jul 30, 2019·Annals of Internal Medicine·Jorge A Wong, P J Devereaux
Feb 20, 2020·Journal of Arrhythmia·Fang Shawn FooUNKNOWN ANZACS‐QI investigators
Mar 3, 2020·Journal of cardiology·Michael SpartalisGerasimos Siasos

❮ Previous
Next ❯

Citations

Nov 13, 2021·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Nathan EngstromHayley Letson

❮ Previous
Next ❯

Methods Mentioned

BETA
coronary artery bypass
Coronary Artery
Percutaneous

Software Mentioned

Cardiobase

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.