Primary prevention of atrial fibrillation: does the atrial lead position influence the incidence of atrial arrhythmias in patients with sinus node dysfunction? Results from the PASTA Trial

Pacing and Clinical Electrophysiology : PACE
Stefan G SpitzerPASTA Study Group

Abstract

PASTA (pacing of the atria in sinus node disease) is a prospective and randomized trial, assessing the effect of different atrial lead positions on the atrial fibrillation (AF) incidence in patients with sinus node disease (SND). The atrial lead position is randomized to: (a) free right atrial wall, (b) right atrial appendage (RAA), (c) coronary sinus ostium (CS-Os), or (d) dual site right atrial pacing (CS-Os + RAA). The pacemakers (Vitatron Selection 9000 or Prevent AF, Vitatron B.V., Arnhem, The Netherlands) are programmed in DDDR 70 mode and the total follow-up duration is 24 months. To describe the atrial rhythm state, pacemaker-derived data (arrhythmia counter) were assessed for AF episodes. AF was considered as evident, if the AF burden (time in AF related to follow-up interval) was >1% (i.e., 15 min/d). Follow-up data after 24 months were evaluated. The analysis evaluates 142 patients (77 male, 74.5 +/- 7.8 years). There was no statistical significant difference with respect to the occurrence of AF between the four groups after 24 months (A: 36%; B: 38%, C: 32%, D: 48%). The percentage of atrial/ventricular pacing was in A: 78/76%, in B: 84/81%, in C: 70/65%, and in D: 79/69%. These differences were not significant. The...Continue Reading

References

Jun 1, 1992·Journal of the American College of Cardiology·A R MisierF J van Capelle
Oct 10, 1997·Circulation·P PapageorgiouM E Josephson
Jun 4, 1999·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·L PadelettiG F Gensini
Jun 7, 2000·Journal of the American College of Cardiology·R BeckerW Schoels
Feb 28, 2001·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·A M Gillis
Jul 14, 2001·Journal of the American College of Cardiology·A C SkanesUNKNOWN Canadian Trial of Physiologic Pacing
Sep 8, 2001·The American Journal of Cardiology·C P LauUNKNOWN New Indication for Preventive Pacing in Atrial Fibrillation (NIPP-AF) Investigators
Oct 2, 2002·Journal of the American College of Cardiology·Sanjeev SaksenaUNKNOWN DAPPAF Investigators
Jan 3, 2003·JAMA : the Journal of the American Medical Association·Bruce L WilkoffUNKNOWN Dual Chamber and VVI Implantable Defibrillator Trial Investigators
Jan 11, 2003·Journal of Cardiovascular Electrophysiology·Mattias DuytschaeverMaurits Allessie
Oct 1, 2003·Pacing and Clinical Electrophysiology : PACE·Bruce S StamblerUNKNOWN Pacemaker Selection in the Elderly Trial Investigators
Dec 18, 2003·Journal of Cardiovascular Electrophysiology·Luigi PadelettiUNKNOWN Worldwide ASPECT Investigators
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·S Adam StrickbergerPaul D Ziegler
Aug 18, 2005·Pacing and Clinical Electrophysiology : PACE·Willem de VoogtJohn Helland
Aug 18, 2005·Pacing and Clinical Electrophysiology : PACE·Azamuddin Khaja, Greg Flaker
Aug 3, 2007·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Willem de VoogtChu-Pak Lau
Sep 7, 2007·The New England Journal of Medicine·Michael O SweeneyUNKNOWN Search AV Extension and Managed Ventricular Pacing for Promoting Atrioventricular Conduction (SAVE PACe) Trial
Sep 28, 2007·European Heart Journal·Paulus KirchhofGünter Breithardt

❮ Previous
Next ❯

Citations

Jun 12, 2013·Circulation·Panos E VardasEmmanuel M Kanoupakis
Sep 27, 2018·Herz·C W IsraelC Berger
Apr 5, 2021·International Journal of Cardiology·Patrice PernolletRodrigue Garcia
Jun 22, 2019·JACC. Clinical Electrophysiology·Rohit K KharbandaNatasja M S de Groot

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.