PMID: 9159601Apr 1, 1997Paper

Primary prevention of coronary heart disease: role of cholesterol control in the United States

Journal of Internal Medicine
S M Grundy

Abstract

The benefit of cholesterol-lowering drug therapy in patients with existing coronary heart disease (CHD) is well established through clinical trials. Prevention of recurrent coronary morbidity and mortality in CHD patients is called secondary prevention. In contrast, primary prevention is delaying or preventing altogether new-onset-CHD. There are three categories of primary prevention: high-risk, moderate-risk, and long-term (life-time). A recent clinical trial has documented benefit of cholesterol-lowering drugs for prevention of coronary morbidity and mortality and total mortality in hyper-cholesterolemic, middle-aged men. This trial lends support for including aggressive cholesterol reduction in high-risk primary prevention. However, for such therapy to be cost effective at present-day prices of cholesterol-lowering drugs, only those patients in the higher ranges of risk can be selected for treatment. This leaves a large number of people at moderately high risk for premature CHD because of high cholesterol levels. These persons deserve increased professional attention to risk reduction. In general the nondrug approach is indicated. The latter approach includes eliminating other risk factors, e.g. cigarette smoking and hyperte...Continue Reading

Citations

Mar 21, 1998·Current Opinion in Lipidology·F W Hanna
Jun 1, 2012·Lipids in Health and Disease·Lin MiaoWei-Xiong Lin
Jul 9, 2002·Best Practice & Research. Clinical Obstetrics & Gynaecology·George I Gorodeski
Feb 27, 1999·Preventive Medicine·R M MerrillE J Feuer
Feb 5, 2004·Journal of the American Dietetic Association·Wendy D PavlovichEric B Bass
Mar 26, 2002·Journal of Occupational and Environmental Medicine·Cheryl PegusJoseph Menzin
Dec 30, 1998·Current Opinion in Lipidology·A D Marais
Sep 5, 2019·Current Computer-aided Drug Design·David Mary RajatheiSamuel Selvaraj
Jun 15, 2007·Bioorganic & Medicinal Chemistry·Larry D BrattonPaul C Unangst

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