Primary primitive neuroectodermal tumor of the cervix: A report of two cases and review of the literature

Molecular and Clinical Oncology
Xiaofeng WangPengpeng Qu

Abstract

Peripheral primitive neuroectodermal tumor (PNET) of the cervix uteri is extremely rare. Two cases of PNET of the cervix are presented herein. Two female patients, aged 48 and 43 years, presented with irregular uterine bleeding over the course of 1 year, and increased urinary frequency for 1 month, respectively. On gynecological examination, a mass in the cervix was palpated and a biopsy performed. The findings of the initial biopsy revealed small-cell carcinoma in both patients. Following neoadjuvant chemotherapy and radiotherapy, radical hysterectomy was performed in both patients. One patient received 5 courses of consolidation chemotherapy and postoperative radiotherapy, whereas the other patient received 1 course of consolidation chemotherapy. At the time of the article submission, both patients remained disease-free at 27 and 12 months, respectively, after their initial diagnosis. Only a limited number of cases of PNET of the cervix uteri have been reported in the literature to date. Multimodal therapies, including total excision, adjuvant chemotherapy and/or radiotherapy, have been adopted to treat patients with PNET of the cervix.

References

Oct 1, 1973·Cancer·M N Hart, K M Earle
Aug 1, 1993·The American Journal of Surgical Pathology·G M KleinmanR E Scully
Oct 1, 1996·The Tohoku Journal of Experimental Medicine·S SatoH Sakuma
Feb 24, 1998·Journal of Pediatric Surgery·C KimberA Pierro
Feb 25, 1998·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·G CenacchiM Derenzini
Feb 9, 2000·Virchows Archiv : an International Journal of Pathology·P PauwelsH van den Berghe
Oct 5, 2001·Gynecologic Oncology·A S TsaoJ A Hurteau
Oct 12, 2002·Annals of Diagnostic Pathology·Anais Malpica, Cesar A Moran
Jun 9, 2005·Hematology/oncology Clinics of North America·Richard Carvajal, Paul Meyers
Feb 3, 2007·Japanese Journal of Clinical Oncology·Yukihide Iwamoto
Jun 15, 2007·Journal of Clinical Pathology·W Glenn McCluggageCyril Fisher
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Jan 29, 2008·The American Journal of Surgical Pathology·Elizabeth D EuscherAnais Malpica
Dec 27, 2008·American Journal of Obstetrics and Gynecology·Jay P ShahJohn M Malone
Oct 13, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Handan CetinerMetin Ozdemirli
Dec 31, 2009·Journal of Lower Genital Tract Disease·Vatsla DadhwalSuneeta Mittal
Sep 6, 2011·International Journal of Clinical Oncology·Prithviraj BoseJennifer L Holter
Oct 4, 2011·Journal of Medical Case Reports·Farah FarzanehFarzaneh Rahimi
Jul 31, 2012·Journal of Pediatric and Adolescent Gynecology·Jie YangHonghui Shi
Sep 5, 2012·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·N AroraA Majumdar
Jan 28, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Changji XiaoQuancai Cui

❮ Previous
Next ❯

Citations

Jul 28, 2018·The Journal of Obstetrics and Gynaecology Research·Munetoshi AkazawaKenichi Taguchi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.