Primary prophylaxis for venous thromboembolism in people undergoing major amputation of the lower extremity.

The Cochrane Database of Systematic Reviews
David Rb HerlihyVikram Puttaswamy

Abstract

People undergoing major amputation of the lower limb are at increased risk of venous thromboembolism (VTE). Risk factors for VTE in amputees include advanced age, sedentary lifestyle, longstanding arterial disease and an identifiable hypercoagulable condition. Evidence suggests that pharmacological prophylaxis (e.g. heparin, factor Xa inhibitors, vitamin K antagonists, direct thrombin inhibitors, antiplatelets) is effective in preventing deep vein thrombosis (DVT), but is associated with an increased risk of bleeding. Mechanical prophylaxis (e.g. antiembolism stockings, intermittent pneumatic compression and foot impulse devices), on the other hand, is non-invasive and has minimal side effects. However, mechanical prophylaxis is not always appropriate for people with contraindications such as peripheral arterial disease (PAD), arteriosclerosis or bilateral lower limb amputations. It is important to determine the most effective thromboprophylaxis for people undergoing major amputation and whether this is one treatment alone or in combination with another. This is an update of the review first published in 2013. To determine the effectiveness of thromboprophylaxis in preventing VTE in people undergoing major amputation of the low...Continue Reading

References

Aug 1, 1975·Archives of Surgery·T H CoveyA E Baue
Nov 1, 1989·Anaesthesia and Intensive Care·C R Goucke
Oct 1, 1973·The British Journal of Surgery·D R HarperP W Woodruff
Nov 1, 1995·Journal of Vascular Surgery·R A YeagerJ M Porter
Jul 1, 1996·Drugs·G F Pineo, R D Hull
Jul 27, 1999·The British Journal of Surgery·G Libertiny, L Hands
Apr 1, 2000·American Journal of Physical Medicine & Rehabilitation·B BurkeE Scremin
Sep 28, 2000·The American Journal of Gastroenterology·H T SørensenJ H Olsen
Nov 22, 2001·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·K A Bauer
Mar 27, 2002·Blood Reviews·J G Kelton
Aug 23, 2002·Southern Medical Journal·Timothy R DillinghamEllen J MacKenzie
Oct 3, 2002·The Medical Journal of Australia·John W Eikelboom, Graeme J Hankey
Oct 31, 2003·The New England Journal of Medicine·H R BüllerUNKNOWN Matisse Investigators
Nov 25, 2003·Diabetes Care·UNKNOWN American Diabetes Association
Jan 28, 2004·Annals of Surgery·Rhys J Morris, John P Woodcock
Jul 30, 2004·Seminars in Thrombosis and Hemostasis·Theodore E Warkentin
Sep 2, 2004·Circulation·Jeffrey I Weitz
Jan 11, 2005·Archives of Physical Medicine and Rehabilitation·Mark E HuangKim Sanford
Oct 6, 2005·Thrombosis Journal·Massimo Franchini
Jun 22, 2007·Vascular Health and Risk Management·Nicolas W Shammas
Nov 6, 2007·Prosthetics and Orthotics International·M HeikkinenJ Salenius
Feb 26, 2008·Archives of Physical Medicine and Rehabilitation·Kathryn Ziegler-GrahamRon Brookmeyer
Apr 26, 2008·BMJ : British Medical Journal·Gordon H GuyattUNKNOWN GRADE Working Group
Dec 31, 2009·Journal of Thrombosis and Haemostasis : JTH·M C Struijk-MulderH R Büller
Dec 9, 2010·Journal of Thrombosis and Haemostasis : JTH·M C Struijk-MulderH B Ettema
Jan 31, 2012·Journal of Blood Medicine·Emeka KesiemeAndrew Dongo
Dec 18, 2013·The Cochrane Database of Systematic Reviews·Lindsay Robertson, Aidan Roche
Apr 25, 2015·Revista da Associação Médica Brasileira·Ivan Benaduce Casella, Pedro Puech-Leão
May 28, 2016·Journal of the American College of Cardiology·Benjamin S SalterGregory W Fischer
Jun 24, 2016·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Naseer AhmadFrancesco Torella

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Cochrane Database of Systematic Reviews
Zhiliang ZuoQiukui Hao
© 2021 Meta ULC. All rights reserved