Primary prophylaxis with pegfilgrastim in patients with newly-diagnosed diffuse large B-cell lymphoma: propensity score and instrumental variable analyses.

Leukemia & Lymphoma
Kensuke MatsudaMineo Kurokawa

Abstract

The clinical impact of pegfilgrastim in day-to-day practice remains unclear. This study evaluated the effectiveness of pegfilgrastim compared with daily filgrastim in patients with DLBCL who received the first-cycle of R-CHOP treatment by using a Japanese national inpatient database. Patient characteristics were adjusted by using propensity-score matching and stabilized inverse probability of treatment weighting (IPTW). In 1295 propensity-score-matched pairs, the incidence of febrile neutropenia was significantly lower in the pegfilgrastim group (risk difference 6.1%, 95% CI 4.1%-8.1%) than in the filgrastim group. In the pegfilgrastim group, the length of hospital stay and the total costs were also significantly reduced (percent reduction 34% [95% CI: 31%-37%], percent reduction 12% [95% CI: 9%-15%], respectively). The stabilized IPTW showed comparable results. In day-to-day practice, the simple mode of pegfilgrastim administration may be advantageous.

References

Oct 22, 1987·The New England Journal of Medicine·R D Mosteller
Aug 24, 2000·Epidemiology·J M RobinsB Brumback
Jan 25, 2002·The New England Journal of Medicine·Bertrand CoiffierChristian Gisselbrecht
Dec 19, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M D GreenUNKNOWN International Pegfilgrastim 749 Study Group
Feb 1, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M VoseB C Liang
Dec 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gary H LymanJeffrey Crawford
Apr 28, 2004·Seminars in Oncology·Eric H Westin, Dan L Longo
Sep 24, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gary H LymanRichard I Fisher
Jan 15, 2008·Journal of Health Economics·Joseph V TerzaPaul J Rathouz
Nov 26, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M S AaproUNKNOWN European Organisation for Research and Treatment of Cancer
Apr 5, 2011·Clinical Pharmacokinetics·Bing-Bing Yang, Anna Kido
Mar 7, 2014·Statistics in Medicine·Michael BaiocchiDylan S Small
Jul 15, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas J SmithJames O Armitage
Jul 12, 2017·Annals of Internal Medicine·Tyler J VanderWeele, Peng Ding
May 17, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Masahiro YokoyamaKiyohiko Hatake

❮ Previous
Next ❯

Citations

Mar 23, 2021·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Kensuke MatsudaMineo Kurokawa
Jul 24, 2021·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Kensuke MatsudaMineo Kurokawa

❮ Previous
Next ❯

Related Concepts

Related Feeds

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Related Papers

Clinical Journal of Oncology Nursing
Maureen S Phillips
Clinical Pharmacokinetics
Bing-Bing Yang, Anna Kido
Clinical Advances in Hematology & Oncology : H&O
Andrew Grigg
Pediatric Blood & Cancer
Blandine BeaupainFrench SCN Registry, Service d'Hémato Oncologie Pédiatrique
© 2022 Meta ULC. All rights reserved