Primary prostatic extragastrointestinal stromal tumor: a case report and literature review

The Journal of International Medical Research
Yong-Hao You, Yi Zhang

Abstract

Objective This study was performed to discuss the characteristics, diagnosis, and treatment of primary prostatic extragastrointestinal stromal tumor (EGIST). Methods The case history data of a patient with an EGIST were analyzed and discussed with a literature review. Results The patient was diagnosed with a pelvic tumor, possibly malignant. We ascertained the diagnosis by exploratory surgery and pathological biopsy. The tumor was present in the prostate and infiltrated and pressed against the anterior rectal wall. Pathological biopsy showed that the tumor comprised spindle cells, which were also present at the junction of the tumor and prostate tissue. Immunohistochemically, the tumor cells were positive for CD117, DOG-1, CD34, and smooth muscle actin and negative for S100 and desmin; Ki-67LI was about 10%. These results support the diagnosis of primary prostatic EGIST. Conclusion The rarity and nonspecific clinical manifestation of prostatic EGIST facilitate misdiagnosis. Diagnosis mainly depends on imaging examination and characteristic histopathological and immunohistochemical features, and GIST must be excluded. Surgery is the main treatment method, and imatinib is suggested for unresectable and malignant EGISTs.

References

May 16, 2008·World Journal of Surgical Oncology·Mario Castillo-SangMohammed Y Ahmed
Oct 23, 2012·Rare Tumors·Dimitris FagkrezosCharikleia Triantopoulou
Jul 31, 2013·Cancer Biotherapy & Radiopharmaceuticals·Han WangJihui Wang
Oct 19, 2013·Experimental and Therapeutic Medicine·Zhenyu OuDihong Tang
Oct 31, 2013·Japanese Journal of Clinical Oncology·Jun Ho YiSeung Sam Paik
Jan 1, 2014·World Journal of Gastroenterology : WJG·Takuya WadaTetsuo Mikami
Jan 5, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Christopher L Corless
Apr 10, 2014·Oman Medical Journal·Palankezhe SashidharanKhalid F Kassem
Oct 4, 2014·Molecular and Clinical Oncology·Fan HeLongkun Li
Jan 22, 2015·The World Journal of Men's Health·Jung-Sik HuhSung Dae Kim

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Methods Mentioned

BETA
biopsy
surgical resection

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