Primary pulmonary germ cell tumor with blastomatous differentiation

Chest
R R MillerR C Murray

Abstract

We describe the clinical and pathologic findings of a patient with mixed blastoma-germ cell malignancy primary in the lung. Serum alpha-fetoprotein levels were elevated at presentation, and normalized with anti-germ cell chemotherapy. The resection specimen contained massively necrotic germ cell tumor with viable mature neural tissue, plus viable biphasic blastoma with stromal bone and skeletal muscle differentiation. It is not clear whether the germ cell component represents unusual differentiation of a somatic cell line or whether the blastoma component represents an unusual pattern of teratomatous differentiation.

References

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Citations

Sep 23, 1997·The American Journal of Surgical Pathology·L ArnouldT Petrella
Oct 2, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Patrick H ArchieHelen J Ross
Feb 10, 2009·Pathology, Research and Practice·Florian R FritzscheMatteo Montani
Feb 20, 2007·The Annals of Thoracic Surgery·Sandeep S RanaSuvkanta Biswal
Apr 10, 2002·Pathology International·Kenzo HiroshimaHidemi Ohwada

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