Primary pulmonary intravascular large B-cell lymphoma: A report of three cases and literature review

Oncology Letters
Yingwei ZhangH R Cai

Abstract

The present study aimed to investigate the clinicopathological features of primary intravascular large B-cell lymphoma (IVLBCL) of the lung. The clinical and histopathological data of three patients, and the literature was reviewed. The Ethics Committees of Drum Tower Hospital approved the current study based on the three cases. Fever and respiratory symptoms were the main presenting symptoms. Serum lactate dehydrogenase and C-reactive protein were significantly increased. Diffuse ground glass opacities or nodular consolidations were seen on high resolution computed tomography. Lung biopsy revealed lymphoma cells in the lumen of small blood vessels. Tumor cells expressed cluster of differentiation 20 and melanoma associated antigen (mutated) 1. Primary pulmonary IVLBCL is extremely rare and its prognosis is poor. Full recognition of its clinical character and improvement of the diagnostic awareness may help to reduce missed diagnosis, and facilitate appropriate treatment.

References

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Citations

Aug 9, 2019·Journal of Clinical and Experimental Hematopathology : JCEH·Tsugumi SatohMasanori Yasuda

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Methods Mentioned

BETA
biopsy
flow cytometry
PCR
ESR

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